Liposomal Epigallocatechin-3-Gallate for the Treatment of In-testinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review

Jose Enrique De la Rubia Ortí; Costanza Moneti; Pilar Serrano-Ballesteros; Gloria Castellano; Raquel Bayona-Babiloni; Ana Belén Carriquí-Suárez; María Motos; Belén Proaño; María Benlloch

doi:10.20944/preprints202306.1033.v3

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preprints.org > medicine and pharmacology > complementary and alternative medicine > doi: 10.20944/preprints202306.1033.v3

Preprint Review Version 3 Preserved in Portico This version is not peer-reviewed

Liposomal Epigallocatechin-3-Gallate for the Treatment of In-testinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review

Jose Enrique De la Rubia Ortí

^* ,

Costanza Moneti

Pilar Serrano-Ballesteros

Gloria Castellano

Raquel Bayona-Babiloni

Ana Belén Carriquí-Suárez

^* ,

María Motos

Belén Proaño

María Benlloch

Version 1 : Received: 14 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (09:37:19 CEST)
Version 2 : Received: 9 July 2023 / Approved: 10 July 2023 / Online: 10 July 2023 (09:40:31 CEST)
Version 3 : Received: 19 July 2023 / Approved: 19 July 2023 / Online: 20 July 2023 (07:02:00 CEST)

A peer-reviewed article of this Preprint also exists.

de la Rubia Ortí, J.E.; Moneti, C.; Serrano-Ballesteros, P.; Castellano, G.; Bayona-Babiloni, R.; Carriquí-Suárez, A.B.; Motos-Muñoz, M.; Proaño, B.; Benlloch, M. Liposomal Epigallocatechin-3-Gallate for the Treatment of Intestinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review. Nutrients 2023, 15, 3265. de la Rubia Ortí, J.E.; Moneti, C.; Serrano-Ballesteros, P.; Castellano, G.; Bayona-Babiloni, R.; Carriquí-Suárez, A.B.; Motos-Muñoz, M.; Proaño, B.; Benlloch, M. Liposomal Epigallocatechin-3-Gallate for the Treatment of Intestinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review. Nutrients 2023, 15, 3265.

Abstract

Autism Spectrum Disorder (ASD) is characterized by varying degrees of difficulty in social interaction and communication. These deficits are often associated with gastrointestinal symptoms, indicating alterations in both intestinal microbiota composition and metabolic activities. The intestinal microbiota influences the function and development of the nervous system. In individuals with ASD, there is an increase in bacterial genera such as Clostridium, as well as species involved in the synthesis of branched-chain amino acids (BCAA) like Prevotella copri. Conversely, decreased amounts of Akkermansia muciniphila, and Bifidobacterium spp. are observed. Epigallocatechin gallate (EGCG) is one of the polyphenols with the greatest beneficial activity on microbial growth and its consumption is associated with reduced psychological distress. Therefore, the objective of this review is to analyze how EGCG and its metabolites can improve the microbial dysbiosis present in ASD and its impact on the pathology. The analysis reveals that EGCG inhibits the growth of pathogenic bacteria like Clostridium perfringens and Clostridium difficile. Moreover, it increases the abundance of Bifidobacterium spp. and Akkermansia spp. As a result, EGCG demonstrates efficacy in increasing the production of metabolites involved in maintaining epithelial integrity and improving brain function. This identifies EGCG as highly promising for complementary treatment in ASD.

Keywords

Autism Spectrum Disorder (ASD); microbiota; epigallocatechin-3-gallate (EGCG); inflammation; oxidative stress

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 20 July 2023
Commenter: Ana Belén Carriquí Suárez
Commenter's Conflict of Interests: Author

Comment: Small improvements have been made.

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