Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis

Mayu Kobayashi
,
Hideo Wada
* ,
Shunsuke Fukui
,
Yasuaki Shimada
,
Yuuichi Nakazawa
,
Hiroki Mizutani
,
Yuhuko Ichikawa
,
Yuuki Nishiura
,
Isao Moritani
,
Yutaka Yamanaka
,
Hidekazu Inoue
,
Motomu Shimaoka
,
Hideto Shimpo
,
Katsuya Shiraki
*
Version 1 : Received: 31 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (04:53:42 CEST)

How to cite: Kobayashi, M.; Wada, H.; Fukui, S.; Shimada, Y.; Nakazawa, Y.; Mizutani, H.; Ichikawa, Y.; Nishiura, Y.; Moritani, I.; Yamanaka, Y.; Inoue, H.; Shimaoka, M.; Shimpo, H.; Shiraki, K. Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis. Preprints 2023, 2023060031. https://doi.org/10.20944/preprints202306.0031.v1 Kobayashi, M.; Wada, H.; Fukui, S.; Shimada, Y.; Nakazawa, Y.; Mizutani, H.; Ichikawa, Y.; Nishiura, Y.; Moritani, I.; Yamanaka, Y.; Inoue, H.; Shimaoka, M.; Shimpo, H.; Shiraki, K. Detection of a Hypercoagulable State in Patients With Pancreatic Cancer Using a Clot Waveform Analysis. Preprints 2023, 2023060031. https://doi.org/10.20944/preprints202306.0031.v1

Abstract

Background: The patients with cancer, especially pancreas cancer, are frequently associated with thrombosis which is one of causes for poor outcome, and hypercoagulability exists in cancer patients. Hypercoagulability is considered to be caused by thrombin burst. Methods: Activated partial thromboplastin time (APTT), small amount of tissue factor induced FIX activation (sTF/FIXa) assays and thrombin time (TT) using clot waveform analysis (CWA) were performed in 138 patients with malignant neoplasm including pancreas cancer and 66 non-cancer patients. Results: Thrombosis was frequently associated in pancreas cancer and was observed in stage I. CWA-APTT showed that the peak times and heights were markedly long and heigh, respectively, in cancer patients, and the peak times were significantly longer in pancreas cancer patients than benign pancreas diseases, and the 1st DPH was significantly higher in pancreas cancers than other cancers or benign pancreas diseases. CWA-sTF/FIXa showed that the peak times and heights were longer and higher, respectively, in patients with cancer than those without cancers, and that the 1st DPH was significantly higher in pancreas cancers than in other cancers. CWA-TT showed that the peak times were significantly shorter in cancer patients than in healthy volunteers and that the peak heights were significantly higher in cancer than in benign pancreas diseases. Conclusions: Cancer patients including pancreas cancer were frequently associated with thrombosis due to hypercoagulability with thrombin burst detected by CWA.

Keywords

cancer; pancreatic cancer; CWA; APTT; sTF/FIXa; thrombin time

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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