Casarin, M.; Todesco, M.; Fontanella, C.G.; Morlacco, A.; Dal Moro, F.; Bagno, A. Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields. Processes2023, 11, 2013.
Casarin, M.; Todesco, M.; Fontanella, C.G.; Morlacco, A.; Dal Moro, F.; Bagno, A. Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields. Processes 2023, 11, 2013.
Casarin, M.; Todesco, M.; Fontanella, C.G.; Morlacco, A.; Dal Moro, F.; Bagno, A. Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields. Processes2023, 11, 2013.
Casarin, M.; Todesco, M.; Fontanella, C.G.; Morlacco, A.; Dal Moro, F.; Bagno, A. Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields. Processes 2023, 11, 2013.
Abstract
The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement of damaged tissues and organs, and able to perfectly integrate with the host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent the best option, but they are often limited due to the low availability of compatible healthy tissues. So far, one therapeutic approach relies on the exploitation of synthetic materials: they exhibit good features in terms of impermeability, deformability and flexibility, but present chronic risks of infections and inflammations. Alternatively, biological materials, including naturally derived ones and acellular tissue matrices of human or animal origin, can be used to induce cells growth and differentiation, which are needed for tissue regeneration: however, this kind of materials lacks satisfactory mechanical resistance and reproducibility, affecting their clinical application.
In order to overcome the above-mentioned limitations, hybrid materials, which can be obtained by coupling synthetic polymers and biological materials, have been investigated with the aim to improve biological compatibility and mechanical features. Currently, the interest in these mate-rials is growing, but the ideal ones have not been found yet.
The present review aims at exploring some applications of hybrid materials, with particular mention to urological and cardiovascular fields: in the first case, the efforts to find a construct that can guarantee impermeability, mechanical resistance and patency will be herein illustrated; in the second case, the search for impermeability, hemocompatibility and adequate compliance will be been disclosed.
Keywords
Biomaterials; Hybrid Materials; Tissue Engineering; Regenerative Medicine
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
