Review
Version 1
Preserved in Portico This version is not peer-reviewed
Cell-type-specific neuroproteomics of synapses
Version 1
: Received: 18 May 2023 / Approved: 19 May 2023 / Online: 19 May 2023 (15:40:25 CEST)
Version 2 : Received: 10 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (10:44:42 CEST)
Version 2 : Received: 10 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (10:44:42 CEST)
A peer-reviewed article of this Preprint also exists.
Yim, Y.Y.; Nestler, E.J. Cell-Type-Specific Neuroproteomics of Synapses. Biomolecules 2023, 13, 998. Yim, Y.Y.; Nestler, E.J. Cell-Type-Specific Neuroproteomics of Synapses. Biomolecules 2023, 13, 998.
Abstract
In the last two decades, our knowledge of synaptic proteomes and their relationship to normal brain function and neuropsychiatric disorders has been expanding rapidly through the use of more powerful neuroproteomics approaches. However, mass spectrometry (MS) based neuroproteomics studies of synapses still need cell-type, spatial, and temporal proteome information. With the advancement of sample preparation and MS techniques, we have just begun to identify and understand proteomes within a given cell type, subcellular compartment, and cell-type-specific synapse. Here, we review the progress and limitations of MS-based neuroproteomics of synapses and highlight the recent applications of these approaches in studying neuropsychiatric disorders such as major depressive disorder and substance use disorders. Combining neuroproteomics findings with other omics studies can generate an in-depth, comprehensive map of synaptic proteomes and possibly identify new therapeutic targets and biomarkers of several central nervous system disorders.
Keywords
Neuroproteomics, synapse, neurological and psychiatric disorders, cell-type specificity
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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