Review
Version 1
Preserved in Portico This version is not peer-reviewed
Mechanobiological Analysis of Nanoparticle Toxicity
Version 1
: Received: 13 May 2023 / Approved: 15 May 2023 / Online: 15 May 2023 (12:39:53 CEST)
A peer-reviewed article of this Preprint also exists.
Ketebo, A.A.; Din, S.U.; Lee, G.; Park, S. Mechanobiological Analysis of Nanoparticle Toxicity. Nanomaterials 2023, 13, 1682. Ketebo, A.A.; Din, S.U.; Lee, G.; Park, S. Mechanobiological Analysis of Nanoparticle Toxicity. Nanomaterials 2023, 13, 1682.
Abstract
Nanoparticles (NPs) are commonly used in healthcare and nano therapy, but their toxicity at high concentrations is well-known. Recent research has shown that NPs can also cause toxicity at low concentrations, disrupting various cellular functions and leading to altered mechanobiological behavior. While researchers have used different methods to investigate the effects of NPs on cells, including gene expression and cell adhesion assays, the use of mechanobiological tools in this context has been underutilized. This review emphasizes the importance of further exploring the mechanobiological effects of NPs, which could reveal valuable insights into the mechanisms behind NP toxicity. Such investigations could aid in developing new strategies to mitigate NP toxicity and improve their safety for biomedical applications. Moreover, understanding how NPs affect cell cytoskeletal functions through mechanobiology could have significant implications, including the development of innovative drug delivery systems and tissue engineering techniques. In summary, this review highlights the significance of incorporating mechanobiology into the study of NP toxicity and demonstrates the potential of this interdisciplinary field to advance our knowledge and practical use of NPs.
Keywords
Nanoparticles; nanotoxicity; mechanobiology; cell cytoskeleton; rigidity sensing
Subject
Biology and Life Sciences, Biophysics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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