Mutant IDH in Gliomas: Role in Cancer and Treatment Options

Georgios Solomou; Alina Finch; Asim Asghar; Chiara Bardella

doi:10.20944/preprints202304.0478.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202304.0478.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mutant IDH in Gliomas: Role in Cancer and Treatment Options

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These authors have contributed equally.

Version 1 : Received: 17 April 2023 / Approved: 18 April 2023 / Online: 18 April 2023 (04:12:06 CEST)
Version 2 : Received: 19 April 2023 / Approved: 20 April 2023 / Online: 20 April 2023 (02:28:47 CEST)

A peer-reviewed article of this Preprint also exists.

Solomou, G.; Finch, A.; Asghar, A.; Bardella, C. Mutant IDH in Gliomas: Role in Cancer and Treatment Options. Cancers 2023, 15, 2883. Solomou, G.; Finch, A.; Asghar, A.; Bardella, C. Mutant IDH in Gliomas: Role in Cancer and Treatment Options. Cancers 2023, 15, 2883.

Abstract

Altered metabolism is a common feature of many cancers and in some cases is a consequence of mutation in metabolic genes, such as the ones involved in Krebs cycle. Isocitrate dehydrogenase (IDH) gene is mutated in many gliomas and other cancers. Physiologically IDH converts isocitrate to αketoglutarate (αKG), but when mutated, IDH reduces αKG to D2-hydroxyglutarate (D2-HG). D2-HG accumulates at high levels in IDH mutant cancers, and in the last decade, a massive effort has been done to develop small inhibitors targeting mutant IDH. In this review, we summarize current knowledge about the cellular and molecular consequences of IDH mutations, and the therapeutic approached developed to target IDH mutant tumours, with a focus on gliomas.

Keywords

isocitrate dehydrogenase, cancer metabolism, hydroxyglutarate, gliomas, oncometabolites

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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