Development and Characterization of Garlic Loaded Chitosan and Chondroitin Sulfate Based Hydrogels for potential Wound Healing/Skin Regeneration Applications

Fatima Masood; Muhammad Atif Makhdoom; Iftikhar Ahmed Channa; Sadaf Jamal Gilani; Ahmad Khan; Rabia Hussain; Syeda Ammara Batool; Kiran Konain; Saeed Ur Rahman; Abdul Wadood; May Nasser Bin-Jumah; Muhammad Atiq ur Rehman

doi:10.20944/preprints202209.0128.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202209.0128.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Development and Characterization of Garlic Loaded Chitosan and Chondroitin Sulfate Based Hydrogels for potential Wound Healing/Skin Regeneration Applications

Fatima Masood

Muhammad Atif Makhdoom

^* ,

Iftikhar Ahmed Channa

Muhammad Atiq ur Rehman

Version 1 : Received: 8 September 2022 / Approved: 9 September 2022 / Online: 9 September 2022 (03:56:12 CEST)

A peer-reviewed article of this Preprint also exists.

Masood, F.; Makhdoom, M.A.; Channa, I.A.; Gilani, S.J.; Khan, A.; Hussain, R.; Batool, S.A.; Konain, K.; Rahman, S.U.; Wadood, A.; bin Jumah, M.N.; Rehman, M.A.U. Development and Characterization of Chitosan and Chondroitin Sulfate Based Hydrogels Enriched with Garlic Extract for Potential Wound Healing/Skin Regeneration Applications. Gels 2022, 8, 676. Masood, F.; Makhdoom, M.A.; Channa, I.A.; Gilani, S.J.; Khan, A.; Hussain, R.; Batool, S.A.; Konain, K.; Rahman, S.U.; Wadood, A.; bin Jumah, M.N.; Rehman, M.A.U. Development and Characterization of Chitosan and Chondroitin Sulfate Based Hydrogels Enriched with Garlic Extract for Potential Wound Healing/Skin Regeneration Applications. Gels 2022, 8, 676.

Abstract

Hydrogels can provide instant relief to pain and facilitate the fast recovery of wounds. Currently the incorporation of medicinal herbs/plants in polymer matrix is being investigated due to their anti-bacterial and wound healing properties. Herein, we investigated the novel combination of chitosan (CS), chondroitin sulfate (CHI) and garlic (Gar) to synthesize hydrogels through freeze gelation process for faster wound healing and resistance to microbial growth at the wound surface. The synthesized hydrogels were characterized via Fourier transform infrared spectroscopy (FTIR), which confirmed the presence of relevant functional groups. The scanning electron microscopy (SEM) images exhibited the porous structure of the hydrogels, which is useful for the sustained release of Gar from the hydrogels. The synthesized hydrogels showed significant inhibition zones against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Furthermore, cell culture studies confirmed the cyto-compatibility of the synthesized hydrogels. Thus, the novel hydrogels presented in this study can offer antibacterial effect during wound healing and promote tissue regeneration.

Keywords

Hydrogels; polymers; regeneration; antibacterial; drug release; garlic; alicin

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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