Recent Progress in Phage Therapy for Controlling Multidrug- Resistant Acinetobacter Baumannii Including in Human and Poultry

Zhang, Y.; Lin, Y.; Galgano, S.; Houdijk, J.; Xie, W.; Jin, Y.; Lin, J.; Song, W.; Fu, Y.; Li, X.; Chui, W.; Kan, W.; Jia, C.; Hu, G.; Li, T. Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, Including in Human and Poultry. Antibiotics 2022, 11, 1406. Zhang, Y.; Lin, Y.; Galgano, S.; Houdijk, J.; Xie, W.; Jin, Y.; Lin, J.; Song, W.; Fu, Y.; Li, X.; Chui, W.; Kan, W.; Jia, C.; Hu, G.; Li, T. Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, Including in Human and Poultry. Antibiotics 2022, 11, 1406.

Abstract

Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and of relevance to poultry production systems. Multidrug-resistant Acinetobacter baumannii has been reported in connection to severe challenges to clinical treatment, mostly due to an increase rate of resistance to carbapenems. Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phage therapy has gained particular importance for the treatment of bacterial infections. This review summarises the different phage-therapy approaches currently in use for multiple-drug resistant Acinetobacter baumannii, including single phage therapy, phage cocktails, phage -antibiotic combination therapy, phage coding Acinetobacter baumannii and the novel phage enzyme treatment. Although phage therapy represents a potential treatment solution for multidrug-resistant Acinetobacter baumannii, further research is needed to unravel some unanswered questions especially in regard to its in vivo applications, before possible routine clinical use.

Keywords

Multidrug-resistant Acinetobacter baumannii; Phage therapy

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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