Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Nanoparticles Impregnated Wound Dressing Material and Its Mechanistic Insight for Chronic Wound Healing: Recent Progress

Manoj Singh
ORCID logo ,
Vanita Thakur
,
Vikas Kumar
ORCID logo ,
Mayank Raj
,
Shivani Gupta
,
Nisha Devi
,
Sushil K. Upadhyay
,
Marketa Macho
,
Avik Banerjee
,
Daniela Ewe
,
Kumar Saurav
* ORCID logo
Version 1 : Received: 24 May 2022 / Approved: 26 May 2022 / Online: 26 May 2022 (08:51:48 CEST)

A peer-reviewed article of this Preprint also exists.

Singh, M.; Thakur, V.; Kumar, V.; Raj, M.; Gupta, S.; Devi, N.; Upadhyay, S.K.; Macho, M.; Banerjee, A.; Ewe, D.; Saurav, K. Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress. Molecules 2022, 27, 5587. Singh, M.; Thakur, V.; Kumar, V.; Raj, M.; Gupta, S.; Devi, N.; Upadhyay, S.K.; Macho, M.; Banerjee, A.; Ewe, D.; Saurav, K. Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress. Molecules 2022, 27, 5587.

Abstract

Wounds are structural and functional disruptions of the skin that occur because of an accident. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during wound healing. Wound healing is a long process that split into at least three continuous and overlapping processes: an inflammatory response, a proliferative phase that leads to tissue repair, and third one is tissue remodeling. Therefore, wound healing studies are extensively studied to develop techniques that can achieve maximum recovery with minimum scar. Several growth hormones and cytokines secreted at the wound site tightly regulate wound healing processes. The traditional approach for wound management has been represented by topical treatments. Metal nanoparticles (e.g., silver, gold, zinc) are increasingly being employed in dermatology due to their favorable effects on wound healing, as well as in treating and preventing bacterial infections. The development of wound dressings materials has now been used to overcome the issues of external environments. The impregnated nanomaterials have provided moist environment that removes the exudates and avoid maceration. This review highlights the mechanism and focus on the current advancement of various nanoparticles impregnation material for wound healing process that can protect wound from infection and maintain the optimum exchange of gases.

Keywords

Wound; Impregnated materials; Nanoparticles; Dermatology

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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