Genetic Background Matters: Population-based Studies in Model Organisms for Translational Research

Valeria Olguín; Anyelo Durán; Macarena Las-Heras; Juan Carlos Rubilar; Francisco A. Cubillos; Patricio Olguín; Andrés D. Klein

doi:10.20944/preprints202205.0314.v1

A peer-reviewed article of this Preprint also exists.

Olguín, V.; Durán, A.; Las Heras, M.; Rubilar, J.C.; Cubillos, F.A.; Olguín, P.; Klein, A.D. Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research. Int. J. Mol. Sci. 2022, 23, 7570. Olguín, V.; Durán, A.; Las Heras, M.; Rubilar, J.C.; Cubillos, F.A.; Olguín, P.; Klein, A.D. Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research. Int. J. Mol. Sci. 2022, 23, 7570.

Abstract

We are all similar, but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly and yeast panels with insightful applications for translational research.

Keywords

systems genetics 1; mouse 2; Drosophila 3; Saccharomyces cerevisiae; translational research 4; genetic background: precision medicine 5; gene mapping 6.

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genetic Background Matters: Population-based Studies in Model Organisms for Translational Research

Abstract

Keywords

Subject

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