Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Marine Natural Product Antimycin A Suppresses Wheat Blast Disease Caused by Magnaporthe oryzae Triticum

Sanjoy Kumar Paul
,
Moutoshi Chakraborty
ORCID logo ,
Mahfuzur Rahman
,
Dipali Rani Gupta
,
Nur Uddin Mahmud
,
Abdullah Al Mahbub Rahat
,
Aniruddha Sarker
ORCID logo ,
Md. Abdul Hannan
ORCID logo ,
Md. Mahbubur Rahman
,
Abdul Mannan Akanda
,
Dr. Jalal Uddin Ahmed
,
Tofazzal Islam
* ORCID logo
Version 1 : Received: 5 May 2022 / Approved: 12 May 2022 / Online: 12 May 2022 (04:02:42 CEST)

A peer-reviewed article of this Preprint also exists.

Paul, S.K.; Chakraborty, M.; Rahman, M.; Gupta, D.R.; Mahmud, N.U.; Rahat, A.A.M.; Sarker, A.; Hannan, M.A.; Rahman, M.M.; Akanda, A.M.; Ahmed, J.U.; Islam, T. Marine Natural Product Antimycin A Suppresses Wheat Blast Disease Caused by Magnaporthe oryzae Triticum. J. Fungi 2022, 8, 618. Paul, S.K.; Chakraborty, M.; Rahman, M.; Gupta, D.R.; Mahmud, N.U.; Rahat, A.A.M.; Sarker, A.; Hannan, M.A.; Rahman, M.M.; Akanda, A.M.; Ahmed, J.U.; Islam, T. Marine Natural Product Antimycin A Suppresses Wheat Blast Disease Caused by Magnaporthe oryzae Triticum. J. Fungi 2022, 8, 618.

Abstract

Application of chemical pesticides to protect agricultural crops from pests and diseases is discouraged due to their harmful effects on human and environment. Therefore, alternative approaches for crop pro-tection through microbial or microbe originated pesticides have been gaining momentum. Wheat blast is a destructive fungal disease caused by Magnaporthe oryzae Triticum (MoT) pathotype, which poses a seri-ous threat to global food security. Screening of secondary metabolites against MoT revealed that antimy-cin A isolated from a marine Streptomyces sp. had significant inhibitory effect on mycelial growth in vitro. This study aimed to investigate the inhibitory effects of antimycin A on some critical life stages of MoT and evaluate the efficacy of wheat blast disease control by this natural product. Bioassay indicated that antimycin A suppressed mycelial growth, conidiogenesis, germination of conidia and formation of ap-pressoria in germinated conidia of MoT in a dose-dependent manner with minimum inhibitory concen-tration 0.005 μg/disk. If germinated, antimycin A induced abnormal germ tubes (4.8%) and suppressed the formation of appressoria. Interestingly, application of antimycin A significantly suppressed wheat blast disease in both seedling and heading stages of wheat supporting the results from invitro study. This is the first report on inhibition of mycelial growth, conidiogenesis, conidia germination, detrimental morphological alterations in germinated conidia, and suppression of wheat blast disease caused by a Triticum pathotype of M. Oryzae. Further study is required to unravel the precise mode of action of this promising natural compound for considering it as a biopesticide to combat wheat blast.

Keywords

Antimycin A; wheat blast; inhibition; biopesticide; biological control

Subject

Biology and Life Sciences, Agricultural Science and Agronomy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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