Chitosan Scaffolds for Cardiac Tissue Engineering

Jorge A. Roacho-Pérez; Elsa N. Garza-Treviño; Nidia K. Moncada-Saucedo; Pablo A. Carriquiry-Chequer; Laura E. Valencia-Gómez; E. Renee Matthews; Víctor Gómez-Flores; Mario Simental-Mendía; Paulina Delgado-Gonzalez; Juan Luis Delgado-Gallegos; Gerardo R. Padilla-Rivas; Jose Francisco Islas

doi:10.20944/preprints202203.0305.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202203.0305.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chitosan Scaffolds for Cardiac Tissue Engineering

Jorge A. Roacho-Pérez

Elsa N. Garza-Treviño

Nidia K. Moncada-Saucedo

Pablo A. Carriquiry-Chequer

Laura E. Valencia-Gómez

E. Renee Matthews

Víctor Gómez-Flores

Mario Simental-Mendía

Paulina Delgado-Gonzalez

Juan Luis Delgado-Gallegos

Gerardo R. Padilla-Rivas

Jose Francisco Islas

Version 1 : Received: 19 March 2022 / Approved: 23 March 2022 / Online: 23 March 2022 (03:12:40 CET)

A peer-reviewed article of this Preprint also exists.

Roacho-Pérez, J.A.; Garza-Treviño, E.N.; Moncada-Saucedo, N.K.; Carriquiry-Chequer, P.A.; Valencia-Gómez, L.E.; Matthews, E.R.; Gómez-Flores, V.; Simental-Mendía, M.; Delgado-Gonzalez, P.; Delgado-Gallegos, J.L.; et al. Artificial Scaffolds in Cardiac Tissue Engineering. Life 2022, 12, 1117. https://doi.org/10.3390/life12081117 Roacho-Pérez, J.A.; Garza-Treviño, E.N.; Moncada-Saucedo, N.K.; Carriquiry-Chequer, P.A.; Valencia-Gómez, L.E.; Matthews, E.R.; Gómez-Flores, V.; Simental-Mendía, M.; Delgado-Gonzalez, P.; Delgado-Gallegos, J.L.; et al. Artificial Scaffolds in Cardiac Tissue Engineering. Life 2022, 12, 1117. https://doi.org/10.3390/life12081117

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Cardiovascular diseases complication can give rise to myocardial infarction which produces cell death by blockage of blood flow, leading to loss of heart function. Current treatments directed at heart repair have several disadvantages such as the lack of donors for heart transplantation or the use of non-bioactive inert materials for replacement of the damage tissue. New treatment strategies involve stimulation of heart tissue regeneration with the use of bioactive materials like chitosan, in combination with cells and biochemical factors. Chitosan scaffolds have the necessary proprieties of biocompatibility, porosity, and biodegradation, that imitates the heart extracellular matrix. Chitosan scaffolds physical proprieties, such as electrical conductivity and mechanical proprieties, can be improved by different preparation techniques and by the functionalization with other materials.

Keywords

chitosan; cardiac tissue engineering; scaffolds

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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