Article
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Preserved in Portico This version is not peer-reviewed
Hydrophilic CO-releasing material of PEGlyated Ruthenium Carbonyl Complex
Version 1
: Received: 19 February 2022 / Approved: 22 February 2022 / Online: 22 February 2022 (03:38:19 CET)
A peer-reviewed article of this Preprint also exists.
Zhang, X.; Guo, N.; Yang, S.; Khan, H.; Zhang, W. Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex. Materials 2022, 15, 3597. Zhang, X.; Guo, N.; Yang, S.; Khan, H.; Zhang, W. Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex. Materials 2022, 15, 3597.
Abstract
The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton were grafted with water-soluble PEGlyated sidearms. Twelve PEGlyted sawhorse Ru2(CO)4 complexes were prepared with satisfactory yields and characterized by IR and 1H- and 13C- NMR. X-ray diffraction analysis of CO-RM 8, 13 and 14 revealed the featured diruthenium sawhorse skeleton and PEGylated axial ligands. The flask-shaking method measures the hydrophilicity of CO-RMs, indicating that both bridging carboxylate ligand and PEGlyated axial ligands regulate the hydrophilicity of these CO-RMs. Under photolysis conditions, CO-RM 4-13 sustainable released therapeutic amounts of CO in myoglobin assay. The correlation of the CO release kinetics and hydrophilicity of CO-RMs demonstrated that the more hydrophilic CO-RM released CO faster. The biological test found the low cytotoxic CO-RM 4 showed a specific anticancer activity toward HT-29 tumour cells.
Keywords
Ruthenium complex; Carbon monoxide releasing molecule; Hydrophilicity, PEGylation
Subject
Chemistry and Materials Science, Biomaterials
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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