Zhang, X.; Guo, N.; Yang, S.; Khan, H.; Zhang, W. Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex. Materials2022, 15, 3597.
Zhang, X.; Guo, N.; Yang, S.; Khan, H.; Zhang, W. Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex. Materials 2022, 15, 3597.
The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton were grafted with water-soluble PEGlyated sidearms. Twelve PEGlyted sawhorse Ru2(CO)4 complexes were prepared with satisfactory yields and characterized by IR and 1H- and 13C- NMR. X-ray diffraction analysis of CO-RM 8, 13 and 14 revealed the featured diruthenium sawhorse skeleton and PEGylated axial ligands. The ﬂask-shaking method measures the hydrophilicity of CO-RMs, indicating that both bridging carboxylate ligand and PEGlyated axial ligands regulate the hydrophilicity of these CO-RMs. Under photolysis conditions, CO-RM 4-13 sustainable released therapeutic amounts of CO in myoglobin assay. The correlation of the CO release kinetics and hydrophilicity of CO-RMs demonstrated that the more hydrophilic CO-RM released CO faster. The biological test found the low cytotoxic CO-RM 4 showed a specific anticancer activity toward HT-29 tumour cells.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.