Version 1
: Received: 9 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (14:18:38 CET)
Version 2
: Received: 22 February 2022 / Approved: 22 February 2022 / Online: 22 February 2022 (10:48:34 CET)
Version 3
: Received: 24 June 2022 / Approved: 27 June 2022 / Online: 27 June 2022 (05:07:50 CEST)
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Abstract
Like living organisms, cancer cells require energy to survive and interact with their environment. Mitochondria are the main organelles for energy production and cellular metabolism. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the cancer puzzle, the ‘dependence’ on the normal cells. This article illustrates the benefits of new, functional mitochondria for cancer cells that urge them to hijack mitochondria. It describes how functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, progression, and treatment resistance. Recent evidence has put forward the pivotal role of mitochondria in cancer stem cells’ metabolism. This theory highlights the mitochondria in cancer biology and explains how targeted anti-mitochondrial treatments can improve oncological outcomes.
Keywords
ATP; Cancer cell; Cancer Treatment; Mitochondria; T cell
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Farzad Taghizadeh-Hesary
Commenter's Conflict of Interests: Author
2. The theory is extended to cancer stem cells.
3. One co-author is added.