Preprint Hypothesis Version 3 Preserved in Portico This version is not peer-reviewed

Targeted Anti-mitochondrial Therapy: The Future of Oncology

Version 1 : Received: 9 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (14:18:38 CET)
Version 2 : Received: 22 February 2022 / Approved: 22 February 2022 / Online: 22 February 2022 (10:48:34 CET)
Version 3 : Received: 24 June 2022 / Approved: 27 June 2022 / Online: 27 June 2022 (05:07:50 CEST)

How to cite: Taghizadeh-Hesary, F.; Behnam, B.; Akbari, H.; Bahadori, M. Targeted Anti-mitochondrial Therapy: The Future of Oncology. Preprints 2022, 2022010171 (doi: 10.20944/preprints202201.0171.v3). Taghizadeh-Hesary, F.; Behnam, B.; Akbari, H.; Bahadori, M. Targeted Anti-mitochondrial Therapy: The Future of Oncology. Preprints 2022, 2022010171 (doi: 10.20944/preprints202201.0171.v3).

Abstract

Like living organisms, cancer cells require energy to survive and interact with their environment. Mitochondria are the main organelles for energy production and cellular metabolism. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the cancer puzzle, the ‘dependence’ on the normal cells. This article illustrates the benefits of new, functional mitochondria for cancer cells that urge them to hijack mitochondria. It describes how functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, progression, and treatment resistance. Recent evidence has put forward the pivotal role of mitochondria in cancer stem cells’ metabolism. This theory highlights the mitochondria in cancer biology and explains how targeted anti-mitochondrial treatments can improve oncological outcomes.

Keywords

ATP; Cancer cell; Cancer Treatment; Mitochondria; T cell

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

Comments (1)

Comment 1
Received: 27 June 2022
Commenter: Farzad Taghizadeh-Hesary
Commenter's Conflict of Interests: Author
Comment: 1. The main title is updated.
2. The theory is extended to cancer stem cells.
3. One co-author is added. 
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