Version 1
: Received: 9 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (14:18:38 CET)
Version 2
: Received: 22 February 2022 / Approved: 22 February 2022 / Online: 22 February 2022 (10:48:34 CET)
Version 3
: Received: 24 June 2022 / Approved: 27 June 2022 / Online: 27 June 2022 (05:07:50 CEST)
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Taghizadeh-Hesary, F.; Akbari, H.; Bahadori, M.; Behnam, B. Targeted Anti-Mitochondrial Therapy: The Future of Oncology. Genes, 2022, 13, 1728. https://doi.org/10.3390/genes13101728.
Abstract
Like living organisms, cancer cells require energy to survive and interact with their environment. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the puzzle of cancer, the ‘dependence’. This article illustrates how new, functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, and progression. In addition, we postulate how blocking the routes cancer cell applies to boost its mitochondria content and function can improve the treatment outcomes of radiotherapy, chemotherapy, and immunotherapy. Besides, this article provides a new theory in oncology, the ‘energy battle’ between cancer and immune cells. It alludes that each party with a higher energy level can win the battle. This theory explains cancer biogenesis and provides novel insights to improve treatment outcomes.
Keywords
ATP; Cancer cell; Cancer Treatment; Mitochondria; T cell
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Farzad Taghizadeh-Hesary
Commenter's Conflict of Interests: Author