Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Immune Cells vs. Cancer Cells: A Microscopic Energy Battle

Version 1 : Received: 9 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (14:18:38 CET)
Version 2 : Received: 22 February 2022 / Approved: 22 February 2022 / Online: 22 February 2022 (10:48:34 CET)
Version 3 : Received: 24 June 2022 / Approved: 27 June 2022 / Online: 27 June 2022 (05:07:50 CEST)

A peer-reviewed article of this Preprint also exists.

11 citations 9 citations in 2 citations in 11 citations 9 citations in 2 citations in

Journal reference: Genes 2022
DOI: 10.3390/genes13101728


Like living organisms, cancer cells require energy to survive and interact with their environment. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the puzzle of cancer, the ‘dependence’. This article illustrates how new, functional mitochondria help cancer cells to survive in the harsh tumor microenvironment, evade immune cells, and improve their malignancy. Finally, we will discuss how blocking the routes supplying energy for cancer cells can improve the treatment outcomes of radiotherapy, chemotherapy, and immunotherapy. This article provides a new theory in oncology, the ‘energy battle’ between cancer and immune cells. It alludes each party with a higher energy level can be the winner. This theory explains cancer biogenesis and provides novel insights to improve treatment outcomes.


ATP; Cancer cell; Mitochondria; T cell


MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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