Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma

Version 1 : Received: 23 December 2021 / Approved: 24 December 2021 / Online: 24 December 2021 (11:41:19 CET)

A peer-reviewed article of this Preprint also exists.

Olímpio, F.A.; Falcão, L.F.M.; Carvalho, M.L.G.; da Costa Lopes, J.; Mendes, C.C.H.; Filho, A.J.M.; da Silva, C.A.M.; Miranda, V.S.C.; Santos, L.C.; da Silva Vilacoert, F.S.; Cruz, A.C.R.; Galúcio, V.C.A.; da Silva Azevedo, R.S.; Martins, L.C.; Duarte, M.I.S.; Sousa, J.R.; da Costa Vasconcelos, P.F.; Quaresma, J.A.S. Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma. Pathogens 2022, 11, 101. Olímpio, F.A.; Falcão, L.F.M.; Carvalho, M.L.G.; da Costa Lopes, J.; Mendes, C.C.H.; Filho, A.J.M.; da Silva, C.A.M.; Miranda, V.S.C.; Santos, L.C.; da Silva Vilacoert, F.S.; Cruz, A.C.R.; Galúcio, V.C.A.; da Silva Azevedo, R.S.; Martins, L.C.; Duarte, M.I.S.; Sousa, J.R.; da Costa Vasconcelos, P.F.; Quaresma, J.A.S. Endothelium Activation during Severe Yellow Fever Triggers an Intense Cytokine-Mediated Inflammatory Response in the Liver Parenchyma. Pathogens 2022, 11, 101.

Journal reference: Pathogens 2022, 11, 101
DOI: 10.3390/pathogens11010101

Abstract

Yellow fever (YF) is a pansystemic disease caused by the yellow fever virus (YFV), the prototype species of the family Flaviviridae and genus Flavivirus, and has a highly complex host-pathogen relationship, in which endothelial dysfunction reflects viral disease tropism. In this study, the in situ endothelial response was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died due to the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of E-selectin, P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and very late antigen-4 in YFV-positive cases than in flavivirus-negative controls. These results indicate that endothelium activation aggravates the inflammatory response by inducing the expression of adhesion molecules that contribute to the rolling, recruitment, migration, and construction of the inflammatory process in the hepatic parenchyma in fatal YF cases.

Keywords

Yellow fever; Liver; Vascular endothelium; Adhesion molecule.

Subject

LIFE SCIENCES, Virology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.