Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Polypropylene Graft Poly(Methyl Methacrylate) Graft Poly(N-Vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery

Felipe López-Saucedo
* ORCID logo ,
Jesús Eduardo López-Barriguete
,
Guadalupe Gabriel Flores-Rojas
,
Sharemy Gómez-Dorantes
ORCID logo ,
Emilio Bucio
* ORCID logo
Version 1 : Received: 26 November 2021 / Approved: 29 November 2021 / Online: 29 November 2021 (15:04:44 CET)

A peer-reviewed article of this Preprint also exists.

López-Saucedo, F.; López-Barriguete, J.E.; Flores-Rojas, G.G.; Gómez-Dorantes, S.; Bucio, E. Polypropylene Graft Poly(Methyl Methacrylate) Graft Poly(N-Vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery. Int. J. Mol. Sci. 2022, 23, 304. López-Saucedo, F.; López-Barriguete, J.E.; Flores-Rojas, G.G.; Gómez-Dorantes, S.; Bucio, E. Polypropylene Graft Poly(Methyl Methacrylate) Graft Poly(N-Vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery. Int. J. Mol. Sci. 2022, 23, 304.

DOI: 10.3390/ijms23010304

Abstract

Surface modification of polypropylene (PP) films is achieved using gamma-irradiation-induced grafting to proffer with antimicrobial activity. The copolymer was obtained through a versatile two-step route; pristine PP is exposed to gamma rays and grafted using methyl methacrylate (MMA), then N-vinylimidazole (NVI) is grafted onto the copolymer PP-g-MMA by simultaneous irradiation. The characterization included Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Thermogravimetric Analysis (TGA), X-ray Photoelectron Spectroscopy (XPS), and physicochemical analysis of swelling and contact angle. The copolymer (PP-g-MMA)-g-NVI was loaded with vancomycin, and the drug released was quantified by UV-vis spectrophotometry at different pH. The surface of (PP-g-MMA)-g-NVI exhibited pH-responsiveness and moderate hydrophilicity, suitable properties for controlled drug release.

Keywords

grafting; polypropylene; gamma rays; methyl methacrylate; N-vinylimidazole; pH-responsiveness; vancomycin; release

Subject

MATERIALS SCIENCE, Surfaces, Coatings & Films

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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