Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Long-Term Evaluation of the Poly(Lactic Acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Version 1 : Received: 7 November 2021 / Approved: 8 November 2021 / Online: 8 November 2021 (13:43:50 CET)

A peer-reviewed article of this Preprint also exists.

Carvalho, J.R.G.; Conde, G.; Antonioli, M.L.; Santana, C.H.; Littiere, T.O.; Dias, P.P.; Chinelatto, M.A.; Canola, P.A.; Zara, F.J.; Ferraz, G.C. Long-Term Evaluation of Poly(Lactic Acid) (PLA) Implants in a Horse: An Experimental Pilot Study. Molecules 2021, 26, 7224. Carvalho, J.R.G.; Conde, G.; Antonioli, M.L.; Santana, C.H.; Littiere, T.O.; Dias, P.P.; Chinelatto, M.A.; Canola, P.A.; Zara, F.J.; Ferraz, G.C. Long-Term Evaluation of Poly(Lactic Acid) (PLA) Implants in a Horse: An Experimental Pilot Study. Molecules 2021, 26, 7224.

Journal reference: Molecules 2021, 26, 7224
DOI: 10.3390/molecules26237224

Abstract

In horses, there is an increasing interest in developing long-lasting drug formulations, with bi-opolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pressing at 180 ºC. Six samples were implanted subcutaneously on the lateral surface of the neck of one horse. The polymers remained implanted for 24 to 57 weeks. Physical examination, plasma fibrinogen, and the mechanical noci-ceptive threshold (MNT) were performed. After 24, 28, 34, 38, and 57 weeks, the materials were removed for histochemical analysis using hematoxylin-eosin and scanning electron microscopy (SEM). There were no essential clinical changes. MNT decreased after the implantation procedure, returning to normal after 48h. A foreign body response was observed by histopathologic evalua-tion up to 38 weeks. At 57 weeks, no polymer or fibrotic capsules were identified. SEM showed surface roughness suggesting a biodegradation process, with an increase in the average pore di-ameter. As in the histopathological evaluation, it was not possible to detect the polymer 57 weeks after implantation. PLA showed biocompatible degradation and these findings may contribute to future research in the biomedical area.

Keywords

Biocompatibility; Biodegradation; Biomaterial; Polylactide-based materials; Polymer; Scanning electron microscopy

Subject

MATERIALS SCIENCE, Biomaterials

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