Rani, A.; Saini, K.C.; Bast, F.; Varjani, S.; Mehariya, S.; Bhatia, S.K.; Sharma, N.; Funk, C. A Review on Microorganisms-Derived Products as Potential Antimicrobial Agents. Preprints2021, 2021070237. https://doi.org/10.20944/preprints202107.0237.v1
Rani, A., Saini, K.C., Bast, F., Varjani, S., Mehariya, S., Bhatia, S.K., Sharma, N., & Funk, C. (2021). A Review on Microorganisms-Derived Products as Potential Antimicrobial Agents. Preprints. https://doi.org/10.20944/preprints202107.0237.v1
Rani, A., Neeta Sharma and Christiane Funk. 2021 "A Review on Microorganisms-Derived Products as Potential Antimicrobial Agents" Preprints. https://doi.org/10.20944/preprints202107.0237.v1
Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and micro algae are the auspicious source of vital bioactive compounds. In this review, the existing state of the art re-garding antimicrobial molecules from microorganisms has been summarized. The potential an-timicrobial compounds from actinomycetes, particularly Streptomyces sp.; archaea; fungi including endophytic and marine-derived fungi, mushroom; yeast, and microalgae were briefly described. Furthermore, this review briefly summarized the activity and mode of action of bacteriocins, a ribosomally synthesized antimicrobial peptides product of Eurotium sp., Streptomyces parvulus, S. thermophiles, Lactococcus lactis, etc. Bacteriocins have inherent properties such as targeting multi-ple-drug resistant pathogens, which allows them to be considered next-generation antibiotics. Similarly, Glarea lozoyensis derived antifungal lipohexpeptides i.e., pneumocandins, inhibits 1,3-β-glucan synthase of the fungal cell wall and acts as a precursor for the synthesis of caspo-fungin, is also elaborated. In conclusion, this review highlights the possibility of using microor-ganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical ap-plications. However, more investigations are still required to separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.
Biology and Life Sciences, Immunology and Microbiology
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