Version 1
: Received: 13 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (07:43:34 CEST)
Version 2
: Received: 27 August 2021 / Approved: 31 August 2021 / Online: 31 August 2021 (12:47:33 CEST)
Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms2021, 9, 2075.
Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms 2021, 9, 2075.
Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms2021, 9, 2075.
Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms 2021, 9, 2075.
Abstract
Adenine and thymine homopolymer strings of at least 8 nucleotides (AT 8+mers) were characterized in Salmonella entericasubspecies I. The motif differed between cother taxonomic classes but not between Salmonella enterica serovars. The motif in plasmids was associated with serovar. Approximately 12.3% of the S. enterica motif loci had mutations. Mutability of AT 8+mers suggests that genomes undergo frequent repair to maintain optimal gene content, and that the motif facilitates self-recognition; in addition, serovar diversity is associated with plasmid content. A theory that genome regeneration accounts for both persistence of predominant Salmonella serovars and serovar diversity provides a new framework for investigating root causes of foodborne illness.
Biology and Life Sciences, Agricultural Science and Agronomy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Jean Guard
Commenter's Conflict of Interests: Author