Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Does Maternal Arachidonic Acid Influence the Neurodevelopmental Effects of Docosahexaenoic Acid?

Version 1 : Received: 25 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (12:48:22 CEST)
Version 2 : Received: 26 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (15:11:00 CEST)

How to cite: Basak, S.; Mallick, R.; Banerjee, A.; Pathak, S.; Duttaroy, A.K. Does Maternal Arachidonic Acid Influence the Neurodevelopmental Effects of Docosahexaenoic Acid?. Preprints 2021, 2021040665 (doi: 10.20944/preprints202104.0665.v2). Basak, S.; Mallick, R.; Banerjee, A.; Pathak, S.; Duttaroy, A.K. Does Maternal Arachidonic Acid Influence the Neurodevelopmental Effects of Docosahexaenoic Acid?. Preprints 2021, 2021040665 (doi: 10.20944/preprints202104.0665.v2).

Abstract

During the last trimester of gestation and for the first 18 months after birth, docosahexaenoic acid,22:6n-3 (DHA) and arachidonic acid,20:4n-6 (ARA) deposited within the cerebral cortex at a rapid rate. The mode of action of these two fatty acids and their derivatives at different structural-function and signaling pathways levels in the brain have been continuously emanating. These fatty acids are also involved in various brain developmental processes; however, their mechanisms of action are not yet well known. Recent data suggest that there may be a need for a balanced proportion of ARA and DHA in infant formula due to their complementary benefits. This review describes the importance of maternal preferential transfer of ARA and DHA to support the infant's optimal brain development and growth and functional roles in the brain.

Subject Areas

Arachidonic acid, 20:4n-6; Brain; Docosahexaenoic acid, 22:6n-3; Fetus; Maternal diet; Cognitive; Infants; Neurodevelopment; Neurogenesis

Comments (1)

Comment 1
Received: 26 April 2021
Commenter: Asim K. Duttaroy
Commenter's Conflict of Interests: Author
Comment: Addition of  these authors ias these are missing n the preprint
Sanjay Basak, Rahul Mallick, Antara Banerjee, Surajit Pathak
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