Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

Md. Ataur Rahman; Md Saidur Rahman; MD. Hasanur Rahman; Mohammad Rasheduzzaman; ANM Mamun-Or-Rashid; Md Jamal Uddin; Md Rezanur Rahman; Hongik Hwang; Myung-Geol Pang; Hyewhon Rhim

doi:10.20944/preprints202010.0195.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202010.0195.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

Md. Ataur Rahman

^* ,

Md Saidur Rahman

MD. Hasanur Rahman

Mohammad Rasheduzzaman

Version 1 : Received: 8 October 2020 / Approved: 9 October 2020 / Online: 9 October 2020 (11:07:53 CEST)

How to cite: Rahman, M.A.; Rahman, M.S.; Rahman, M.H.; Rasheduzzaman, M.; Mamun-Or-Rashid, A.; Uddin, M.J.; Rahman, M.R.; Hwang, H.; Pang, M.; Rhim, H. Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease. Preprints 2020, 2020100195. https://doi.org/10.20944/preprints202010.0195.v1 Rahman, M.A.; Rahman, M.S.; Rahman, M.H.; Rasheduzzaman, M.; Mamun-Or-Rashid, A.; Uddin, M.J.; Rahman, M.R.; Hwang, H.; Pang, M.; Rhim, H. Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease. Preprints 2020, 2020100195. https://doi.org/10.20944/preprints202010.0195.v1

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MDPI and ACS Style

Rahman, M.A.; Rahman, M.S.; Rahman, M.H.; Rasheduzzaman, M.; Mamun-Or-Rashid, A.; Uddin, M.J.; Rahman, M.R.; Hwang, H.; Pang, M.; Rhim, H. Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease. Preprints 2020, 2020100195. https://doi.org/10.20944/preprints202010.0195.v1

APA Style

Rahman, M.A., Rahman, M.S., Rahman, M.H., Rasheduzzaman, M., Mamun-Or-Rashid, A., Uddin, M.J., Rahman, M.R., Hwang, H., Pang, M., & Rhim, H. (2020). Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease. Preprints. https://doi.org/10.20944/preprints202010.0195.v1

Chicago/Turabian Style

Rahman, M.A., Myung-Geol Pang and Hyewhon Rhim. 2020 "Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease" Preprints. https://doi.org/10.20944/preprints202010.0195.v1

Abstract

Autophagy refers to the degradation of cytoplasmic constituents by a lysosomal-mediated pathway, which plays a critical role in maintaining cellular homeostasis. Importantly, dysregulation of autophagy has been implicated in multiple neurodegenerative disorders. Previous studies reported that autophagy affects the processing of amyloid precursor protein (APP), thus stimulating β‐amyloid (Aβ) production in Alzheimer’s disease (AD) eventually. Although the mechanism of autophagy modulation on APP processing and its pathogenesis has not yet been fully elucidated at the molecular level, but modulation of autophagy has received considerable attention as a promising approach for the treatment of AD. In the early stage of AD, Aβ may prompt autophagy to facilitate its removal via mTOR‐independent as well as-dependent pathways. However, a recent study proposed that autophagy processes are not properly regulated as AD continues to progress, and consequently, the production of Aβ tends to accumulate rapidly. Meanwhile, a number of autophagy-related genes (Atg) as well as APP genes are also thought to influence the development of AD, which may serve as a bi‐directional link to autophagy and AD pathology. In this review, we summarized current observations related to autophagy regulation and APP processing, focusing on their dynamic modifications associated with the progression of AD. Recent findings together highlight the essential role of autophagy in the removal and clearance of APP and Aβ deposition in the pathological condition of AD.

Keywords

Autophagy; Amyloid precursor protein (APP); β‐amyloid (Aβ); mTOR; Alzheimer’s disease (AD).

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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