Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Biofunctionalization of UHMWPE Polymer and Its Application in Anterior Cruciate Ligament Reconstruction

Version 1 : Received: 2 August 2020 / Approved: 4 August 2020 / Online: 4 August 2020 (03:27:46 CEST)

How to cite: Wahed, S.B.; Dunstan, C.R.; Boughton, P.A.; Ruys, A.J. Biofunctionalization of UHMWPE Polymer and Its Application in Anterior Cruciate Ligament Reconstruction. Preprints 2020, 2020080071 (doi: 10.20944/preprints202008.0071.v1). Wahed, S.B.; Dunstan, C.R.; Boughton, P.A.; Ruys, A.J. Biofunctionalization of UHMWPE Polymer and Its Application in Anterior Cruciate Ligament Reconstruction. Preprints 2020, 2020080071 (doi: 10.20944/preprints202008.0071.v1).

Abstract

The selection of biomaterials for biomedical application is a significant challenge. In the last few decades, various bioabsorbable and stable biopolymers have been applied for use as biomedical devices in orthopedic applications. Ultra-high molecular weight polyethylene (UHMWPE) has been extensively used in medical implants, notably in the bearings of hip, knee, and other joint prostheses, owing to its biocompatibility and high wear resistance. For the ACL graft, synthetic UHMWPE is an ideal candidate due to its biocompatibility and its extremely high tensile strength. Despite the appeal of new advanced materials such as carbon fiber, poly-ether-ether ketone, and other load-bearing materials, UHMWPE remains a primary load-bearing candidate material for ACL reconstructions because of its extremely high strength, the simplicity of the fabrication process, its biocompatibility, and low friction. However, some significant problems are observed in UHMWPE based implants, such as wear debris, and oxidative degradation due to the generation of free radicals when exposed to irradiation with gamma rays for grafting or sterilization. Various innovative methodologies have been developed to resolve those problems and enhance the properties of UHMWPE. In this review, we will explore in detail the methods for surface functionalization of UHMWPE and will apply these findings to the case study of UHMWPE for Anterior Cruciate Ligament repair.

Subject Areas

review; biomaterials; polyethylene; UHMWPE; ACL; Ligament; tendon; plasma treatment; surface modification; synthetic graft; bioactive glass

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