Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 and Covid-19 Immunopathogenesis

Version 1 : Received: 31 July 2020 / Approved: 2 August 2020 / Online: 2 August 2020 (11:53:17 CEST)

How to cite: Boechat, A.L.; Pessoa, B.; Soares, C.; Barroso, C.; Vila, D.; Barbosa, E.; Seffair, I.; Melo, J.V.; Becil, J.; Rebouças, M.P.; Rodrigues, N.; Freitas, P.H.; Rocha, R.; Rodrigues, T.; Ferreira, V.; Ubiera, R.; Dos-Santos, M.C. SARS-CoV-2 and Covid-19 Immunopathogenesis. Preprints 2020, 2020080020 (doi: 10.20944/preprints202008.0020.v1). Boechat, A.L.; Pessoa, B.; Soares, C.; Barroso, C.; Vila, D.; Barbosa, E.; Seffair, I.; Melo, J.V.; Becil, J.; Rebouças, M.P.; Rodrigues, N.; Freitas, P.H.; Rocha, R.; Rodrigues, T.; Ferreira, V.; Ubiera, R.; Dos-Santos, M.C. SARS-CoV-2 and Covid-19 Immunopathogenesis. Preprints 2020, 2020080020 (doi: 10.20944/preprints202008.0020.v1).

Abstract

The coronavirus disease 2019 (COVID-19) is now a global pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Unlike other known coronaviruses, such as the Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 reveals new clinical, immunological, and pathologic features. The lymphocyte depletion, macrophage and neutrophil hyperactivation, cytokine dysregulation, thrombophilia, delayed antiviral response, and immune exhaustion are key immunological findings linked to the clinical progression of this disease. Understanding and identifying the underlying immunological basis of COVID-19 is crucial to designing effective therapies. Here, we provide an overview of immunopathogenesis driven by SARS-CoV-2 after its interactions with the immune system.

Subject Areas

SARS-CoV-2; COVID-19; Immunopathogenesis; Cytokine storm; IL-6; macrophages; neutrophils

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