Preprint Article Version 1 This version is not peer-reviewed

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed High-fat Diet or a High-fat Diet Combined with STZ Treatment

Version 1 : Received: 26 November 2019 / Approved: 27 November 2019 / Online: 27 November 2019 (09:57:14 CET)

How to cite: Xia, Z.; Chen, W.; Shi, L.; Jiang, X.; Li, K.; Wang, Y.; Liu, Y. The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed High-fat Diet or a High-fat Diet Combined with STZ Treatment. Preprints 2019, 2019110343 (doi: 10.20944/preprints201911.0343.v1). Xia, Z.; Chen, W.; Shi, L.; Jiang, X.; Li, K.; Wang, Y.; Liu, Y. The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed High-fat Diet or a High-fat Diet Combined with STZ Treatment. Preprints 2019, 2019110343 (doi: 10.20944/preprints201911.0343.v1).

Abstract

Curcumin is the main secondary metabolites of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study investigated the effect curcumin in inhibiting high-fat diet and streptozotocin (STZ)-induced hyperglycemia and hyperlipidemia in rats. Twenty-six male Sprague-Dawley (SD) rats (170-190 g) were randomly divided into a standard food pellet diet group (Control group), a high-fat diet and streptozotocin group (HF+STZ group), and a high-fat diet combined with curcumin and STZ group (HF+ Cur +STZ group). Compared with the HF+STZ group, the HF+Cur+STZ group exhibited significantly reduced fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (AST) and aspartate transaminase (ALT) levels, and liver coefficients; in the livers of these rats, the expression of malondialdehyde (MDA) and Bax was downregulated, whereas that of superoxide dismutase (SOD) and Bcl-2 was upregulated. Moreover, the liver histology of these rats was improved and resembled that of the control rats. These results suggest that curcumin prevents high-fat diet and STZ-induced hyperglycemia and hyperlipidemia, mainly via anti-oxidant and anti-apoptotic mechanisms in the liver.

Subject Areas

anti-apoptosis; anti-oxidant; curcumin; hyperglycemia; hyperlipidemia

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