Version 1
: Received: 15 November 2019 / Approved: 18 November 2019 / Online: 18 November 2019 (06:34:56 CET)
Version 2
: Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (03:26:40 CET)
How to cite:
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints2019, 2019110213. https://doi.org/10.20944/preprints201911.0213.v1
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints 2019, 2019110213. https://doi.org/10.20944/preprints201911.0213.v1
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints2019, 2019110213. https://doi.org/10.20944/preprints201911.0213.v1
APA Style
Kwon, S., Tisserant, C., Tulinski, M., Weiberg, A., & Feldbrügge, M. (2019). Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints. https://doi.org/10.20944/preprints201911.0213.v1
Chicago/Turabian Style
Kwon, S., Arne Weiberg and Michael Feldbrügge. 2019 "Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport" Preprints. https://doi.org/10.20944/preprints201911.0213.v1
Abstract
Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the RNA cargo and mechanistic details of transport via two inter-related sets of organelles: endosomes and extracellular vesicles for intra- and intercellular RNA transfer. Simultaneous transport and translation of messenger RNAs (mRNAs) on the surface of shuttling endosomes is a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail the endosomal mRNA transport machinery components and mRNA targets of the core RNA-binding protein Rrm4. Extracellular vesicles (EVs) are newly garnering interest as mediators of intercellular communication, especially between pathogenic fungi and their hosts. Landmark studies in plant-fungus interactions indicate EVs as a means of delivering various cargos, most notably small RNAs (sRNAs), for cross-kingdom RNA interference. Recent advances and implications of the nascent field of fungal EVs are discussed and potential links between endosomal and EV-mediated RNA transport are proposed.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
