Preprint Review Version 1 This version is not peer-reviewed

Relationship between Wine Consumption and Alzheimer's Disease

Version 1 : Received: 4 November 2019 / Approved: 6 November 2019 / Online: 6 November 2019 (10:54:00 CET)

How to cite: Reale, M.; D'Angelo, C.; Costantini, E.; Jagarlapoodi, S.; Khan, H.; Belwal, T.; Cichelli, A. Relationship between Wine Consumption and Alzheimer's Disease. Preprints 2019, 2019110060 (doi: 10.20944/preprints201911.0060.v1). Reale, M.; D'Angelo, C.; Costantini, E.; Jagarlapoodi, S.; Khan, H.; Belwal, T.; Cichelli, A. Relationship between Wine Consumption and Alzheimer's Disease. Preprints 2019, 2019110060 (doi: 10.20944/preprints201911.0060.v1).

Abstract

Background: Alzheimer’s disease (AD), the most threatening neurodegenerative diseases, is characterized by the loss of memory and language function, an unbalanced perception of space and other cognitive and physical manifestations. Pathology of the AD is characterized by neuronal loss, and the extensive distribution of senile plaques and neurofibrillary tangles (NFTs). The role of environment and the diet in the AD is being studied actively, and nutrition is certainly one of the main factors playing a prominent role in the prevention of neurodegenerative diseases. In this context, the relationship between dementia and wine use/abuse has received increased research interest in recent times, with varying and often conflicting results. Scope and approach: This review aims to critically summarize the most recent studies conducted to clarify the relationship between wine drinking and AD, as well as whether effects are influenced by quantity and/or frequency of drinking. Key findings and Conclusion: Overall, based on the interpretation of various studies, it can be concluded that there is no indication that light to moderate alcohol drinking is detrimental to cognition and dementia, and it is not possible to define whether alcohol could be used as a means to reduce risk of developing AD.

Subject Areas

alcohol consumption; Alzheimer's disease; light to moderate wine consumption; neurodegeneration

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