Version 1
: Received: 14 June 2019 / Approved: 17 June 2019 / Online: 17 June 2019 (10:53:28 CEST)
How to cite:
Dong, H.; Xiong, F.; Zhong, Q.; Li, Y.; Liu, M.; Ling, W.; Tang, X.; Chen, Y. Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women. Preprints2019, 2019060163. https://doi.org/10.20944/preprints201906.0163.v1
Dong, H.; Xiong, F.; Zhong, Q.; Li, Y.; Liu, M.; Ling, W.; Tang, X.; Chen, Y. Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women. Preprints 2019, 2019060163. https://doi.org/10.20944/preprints201906.0163.v1
Dong, H.; Xiong, F.; Zhong, Q.; Li, Y.; Liu, M.; Ling, W.; Tang, X.; Chen, Y. Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women. Preprints2019, 2019060163. https://doi.org/10.20944/preprints201906.0163.v1
APA Style
Dong, H., Xiong, F., Zhong, Q., Li, Y., Liu, M., Ling, W., Tang, X., & Chen, Y. (2019). Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women. Preprints. https://doi.org/10.20944/preprints201906.0163.v1
Chicago/Turabian Style
Dong, H., Xin-yi Tang and Yu-ming Chen. 2019 "Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women" Preprints. https://doi.org/10.20944/preprints201906.0163.v1
Abstract
Little is known about the association between equol and bioavailable testosterone (BT) in adults. We examined the associations of urinary equol concentrations with serum total, bioavailable and free testosterone (FT), dehydroepiandrosterone sulfide (DHEAS), free androgen index (FAI) and sex hormone-binding globulin (SHBG) concentrations. This cross-sectional study included 1904 women aged 59.7 years. Urinary equol and serum sex hormone concentrations were measured. Overall, urinary equol tended to be inversely associated with bioactive forms of androgenic indices (BT, FT or FAI) but not with total testosterone (TT) or DHEAS. Urinary equol was also positively associated with SHBG. In multi-covariate-adjusted analyses stratified by menopausal status, graded and inverse associations between urinary equol and bioactive forms of androgenic indices (BT, FT and FAI) were observed in postmenopausal women (all p-trends <0.05), but not in premenopausal women. A significant positive association between urinary equol and SHBG was observed only in postmenopausal women. No significant associations were observed between urinary equol and TT or DHEAS in either group. A path analysis indicated that these associations of equol with androgens in postmenopausal women might be mediated by SHBG. Our findings indicated urinary equol exhibited graded and inverse associations with BT or FT but not TT in women.
Keywords
equol; bioavailable testosterone; total testosterone; sex hormone-binding globulin
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
