Preprint Article Version 1 This version is not peer-reviewed

The Antifungal Potential of Sarvacrol against Penicillium digitatum through 1H-NMR Based Metabolomics Approach

Version 1 : Received: 24 May 2019 / Approved: 24 May 2019 / Online: 24 May 2019 (14:33:50 CEST)

A peer-reviewed article of this Preprint also exists.

Wan, C.; Shen, Y.; Nisar, M.F.; Qi, W.; Chen, C.; Chen, J. The Antifungal Potential of Carvacrol against Penicillium Digitatum through 1H-NMR Based Metabolomics Approach. Appl. Sci. 2019, 9, 2240. Wan, C.; Shen, Y.; Nisar, M.F.; Qi, W.; Chen, C.; Chen, J. The Antifungal Potential of Carvacrol against Penicillium Digitatum through 1H-NMR Based Metabolomics Approach. Appl. Sci. 2019, 9, 2240.

Journal reference: Appl. Sci. 2019, 9, 2240
DOI: 10.3390/app9112240

Abstract

Carvacrol has long been studied for its natural antifungal potential and food preservative. But the exact mode of its action remained highly complex as a general, but especially for Penicillium digitatum (P. digitatum) largely remained unexplored. Herein, a 1H-NMR-based metabolomic technique was used to investigate the antifungal mechanism of carvacrol. The metabolomic profiling data showed that alanine, aspartate, glutamate and glutathione metabolism were imbalanced in the fungal hyphae. A strong positive correlation was seen between aspartate, glutamate, alanine and glutamine, while negative correlation among glutathione and lactate. These metabolic changes revealed that carvacrol-induced oxidative stress had disturbed the energy production and amino acid metabolism of P. digitatum. Current study will improve the understanding of the metabolic changes posed by plant-based fungicides in order to control citrus fruit green mold caused by P. digitatum. Moreover, the study will provided certain experimental and theoretical basis for the development of novel citrus fruit preservatives.

Subject Areas

amino acid metabolism; carvacrol; metabolomics data; oxidative stress; Penicillium digitatum

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