Preprint Review Version 1 This version is not peer-reviewed

Microbiota and LPS-Induced Obesity Inflammation: Therapeutic Implications

Version 1 : Received: 18 July 2018 / Approved: 20 July 2018 / Online: 20 July 2018 (04:56:08 CEST)

How to cite: Pero, R.; Fico, G.; Scudiero, O.; Laneri, S. Microbiota and LPS-Induced Obesity Inflammation: Therapeutic Implications . Preprints 2018, 2018070375 (doi: 10.20944/preprints201807.0375.v1). Pero, R.; Fico, G.; Scudiero, O.; Laneri, S. Microbiota and LPS-Induced Obesity Inflammation: Therapeutic Implications . Preprints 2018, 2018070375 (doi: 10.20944/preprints201807.0375.v1).

Abstract

Obesity and chronic low-grade inflammation are becoming global epidemics. The dysbiosis has a specific role in the metabolism and energy stocks of the host. The discovery that a low-grade of inflammation could be directly connected to the intestinal microbiota metabolic endotoxemia (elevated levels of plasma lipopolysaccharides) has allowed the identification of novel mechanisms involved in the control of the intestinal barrier. In this review, it will analyze the latest news to explain how human symbiotic microorganisms participate in the growth of the fat reserves and promote insulin resistance as a low-grade inflammation. Besides, it will discuss new treatments with probiotics and prebiotics as a promising therapeutic approach to reverse the host's metabolic changes linked to dysbiosis observed in obesity.

Subject Areas

LPS; microbiota; inflammation; intestinal permeability; obesity

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.