Preprint Review Version 1 This version is not peer-reviewed

Health concerns of various nanoparticles: A review of their in vitro and in vivo toxicity

Version 1 : Received: 15 June 2018 / Approved: 18 June 2018 / Online: 18 June 2018 (15:32:41 CEST)

How to cite: Ajdari, M.; Moosavi, M.; Rahmati, M.; Falahati, M.; Mahboubi, M.; Mandegary, A.; Jangjoo, S.; Mohammadinejad, R.; Varma, R.S. Health concerns of various nanoparticles: A review of their in vitro and in vivo toxicity. Preprints 2018, 2018060273 (doi: 10.20944/preprints201806.0273.v1). Ajdari, M.; Moosavi, M.; Rahmati, M.; Falahati, M.; Mahboubi, M.; Mandegary, A.; Jangjoo, S.; Mohammadinejad, R.; Varma, R.S. Health concerns of various nanoparticles: A review of their in vitro and in vivo toxicity. Preprints 2018, 2018060273 (doi: 10.20944/preprints201806.0273.v1).

Abstract

Nanoparticles (NPs) are widely used in diverse disciplines, including biology, medicine science. The central question that need to be answered is whether NPs have toxic effects on biological cells and molecules or are they safe. The safety of NPs including targeted drug delivery is critical and so is their toxicity in the environment. In recent years, in vitro and in vivo research on animals has generated abundant information about the toxicity of NPs. However, due to varying laboratory conditions, the comparison of the results from ensuing studies is somewhat unreliable. It should be noted that, depending on the type of production, NPs can enter the body through inhalation, skin and via digestive routes. Due to the diversity of NPs and their properties, there is paucity of accurate information on their toxicological effects; particle size, shape, surface area and the chemical levels are considered as key factors in creating health and toxicological effects. Consequently, there is a need for reliable information about their effects on various organs so as to deal with NPs effectively and their impact on health and the environment. This review covers the existing knowledge base on the subject that hopefully prepares us better to address these challenges.

Subject Areas

Nanoparticles; Toxicological effects; Organ-specific effects

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