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Facile Synthesis of High Molecular Weight Polypeptides via Surface-Initiated Vapor Deposition Polymerization
Version 1
: Received: 30 March 2018 / Approved: 30 March 2018 / Online: 30 March 2018 (10:08:14 CEST)
How to cite: Yang, C.; Wu, J.; Chang, Y. Facile Synthesis of High Molecular Weight Polypeptides via Surface-Initiated Vapor Deposition Polymerization. Preprints 2018, 2018030267 (doi: 10.20944/preprints201803.0267.v1). Yang, C.; Wu, J.; Chang, Y. Facile Synthesis of High Molecular Weight Polypeptides via Surface-Initiated Vapor Deposition Polymerization. Preprints 2018, 2018030267 (doi: 10.20944/preprints201803.0267.v1).
Abstract
Despite huge effort has been devoted to the design of the initiators and reaction conditions, it remains challenging to synthesize high molecular weight polypeptides with conventional solution phase synthesis. In this work, surface-initiated vapor deposition polymerization (SI-VDP) was utilized to graft synthetic polypeptides poly (γ-benzyl L-glutamate) (PBLG) from polystyrene (PS) resin beads by ring-opening polymerization of N-carboxyanhydrides (NCAs). It was demonstrated for the first time that high molecular weight bulk PBLG (> 500,000) could be readily obtained within one hour via solvent-free synthetic method which paves the way for the synthesis of copolypeptides with high molecular weight.
Subject Areas
surface-initiated vapor deposition polymerization; N-carboxyanhydrides; ring-opening polymerization; poly (γ-benzyl L-glutamate); solvent-free polymerization; solid state polypeptide synthesis
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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