Preprint Article Version 1 This version is not peer-reviewed

The Role of Voltage-Gated Sodium Channel (VGSC) Gene Mutations in the Resistance of Aedes aegypti L. to Pyrethroid Permethrin in Palembang and Jakarta, Indonesia

Version 1 : Received: 8 March 2018 / Approved: 9 March 2018 / Online: 9 March 2018 (05:27:12 CET)

How to cite: Islami, S.; Hidayati, A.P.N.; Wibowo, H.; Syafruddin, D. The Role of Voltage-Gated Sodium Channel (VGSC) Gene Mutations in the Resistance of Aedes aegypti L. to Pyrethroid Permethrin in Palembang and Jakarta, Indonesia. Preprints 2018, 2018030070 (doi: 10.20944/preprints201803.0070.v1). Islami, S.; Hidayati, A.P.N.; Wibowo, H.; Syafruddin, D. The Role of Voltage-Gated Sodium Channel (VGSC) Gene Mutations in the Resistance of Aedes aegypti L. to Pyrethroid Permethrin in Palembang and Jakarta, Indonesia. Preprints 2018, 2018030070 (doi: 10.20944/preprints201803.0070.v1).

Abstract

Aedes aegypti mosquito is a vector that could transmit various pathogens, such as viruses, bacteria, and parasites. Several human diseases transmitted by Ae. aegypti mosquito are dengue fever (DHF), Chikungunya, Yellow Fever and Zika. The occurance of resistance to various insecticides, including pyrethroid, is a current problem faced by various countries. In this research, a WHO bioassay test on Palembang and Jakarta Ae. aegypti was conducted using 0.25% permethrin pyrethroid insecticide. VGSC gene fragments associated with pyrethroid resistance (L982, S989, I1011, L1014, V1016 and F1534) of resistant and sensitive strains were amplified and analyzed. The test showed the presence of resistance in Ae. aegypti isolates from Palembang and Jakarta. From the results of VGSC gene fragment analyses, it was known that there were mutations (S989P and/or V1016G) on isolates from Palembang and (S989P and/or V1016G) on resistant isolates from Jakarta.

Subject Areas

Aedes aegypti; insecticide resistance; pyrethroid; permethrin; VGSC gene

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