Elevated Polyamines in Saliva of Pancreatic Cancer

Asai, Y.; Itoi, T.; Sugimoto, M.; Sofuni, A.; Tsuchiya, T.; Tanaka, R.; Tonozuka, R.; Honjo, M.; Mukai, S.; Fujita, M.; Yamamoto, K.; Matsunami, Y.; Kurosawa, T.; Nagakawa, Y.; Kaneko, M.; Ota, S.; Kawachi, S.; Shimazu, M.; Soga, T.; Tomita, M.; Sunamura, M. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers 2018, 10, 43. Asai, Y.; Itoi, T.; Sugimoto, M.; Sofuni, A.; Tsuchiya, T.; Tanaka, R.; Tonozuka, R.; Honjo, M.; Mukai, S.; Fujita, M.; Yamamoto, K.; Matsunami, Y.; Kurosawa, T.; Nagakawa, Y.; Kaneko, M.; Ota, S.; Kawachi, S.; Shimazu, M.; Soga, T.; Tomita, M.; Sunamura, M. Elevated Polyamines in Saliva of Pancreatic Cancer. Cancers 2018, 10, 43.

Abstract

Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (n=39), chronic pancreatitis (CP, n=14) and controls (C, n=26). Polyamines, such as spermine, N1-acetylspermidine, and N1-acetylspermine, showed a significant difference between PC and C, and the combination of four metabolites including N1-acetylspermidine showed high accuracy in discriminating PC from the other two groups. These data showed the potential of saliva as a screening test for PC.

Keywords

pancreatic cancer; saliva; metabolomics; polyamines

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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