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Mapping the vRNA Interaction with HIV-1 Integrase
Jian Sun
,Rahul Yadav
,Tolga Catmakas
,Luke Fisher
,Nicholas C. Fitzkee
,Jacques J. Kessl
Posted: 08 May 2026
Phosphoproteomics and Multi-Omics for Oleanolic Acid Target Deconvolution: From Phosphorylation Signatures to Mechanistic Validation
Andrzej Günther
,Barbara Bednarczyk-Cwynar
Posted: 08 May 2026
Management of Subglottic Foreign Body in Adults: A Case Report and A Brief Review of The Literature
Giada Cavallaro
,Domenico Cifarelli
,Margherita Laguardia
,Guglielmo Larotonda
,Camilla Gallipoli
,Giuseppe De Cillis
,Giacinto Asprella-Libonati
Posted: 08 May 2026
Data-Driven Rank Inference with Certified Sylvester Reconstruction for Robust Binary Waring Decomposition
Wenjie Wang
,Chen-Wei Liang
,Mu-Jiang-Shan Wang
,Chi Zhang
Posted: 08 May 2026
Development of a Gravity Mixer for Energy-Efficient Mixing of Sapropel and Organic Fertilizers
Tokhtar Abilzhanuly
,Daniyar Abilzhanov
,Marat Aldabergenov
,Nursultan Orynbayev
,Sergey Sakhnov
,Olzhas Seipataliyev
,Dauren Kosherbay
Posted: 08 May 2026
Composition-Specific Effects of PM2.5 on Influenza-Like Illness: Independent Roles of Chemical Components and Mixture Profiles in a Multi-City Study
Mingzhao Huang
,Ying Deng
,Xiaolu Zhang
,Yi Yan
,Ying Li
,Luli Xu
,Xiya Qin
,Kai Chen
,Xiaoxuan Fan
,Lianting Hu
+4 authors
Posted: 08 May 2026
When to Route? Regime-Adaptive Meta-Policies for Hierarchical Portfolio Agents
Zhizhuo Kou
,Jian Yang
,Junyu Luo
,Yuyao Zhang
,Sirui Han
,Yike Guo
Posted: 08 May 2026
Shock Wave Structure in a Monatomic Gas Mix with Rydberg Atoms
A. Markhotok
Posted: 08 May 2026
Defective Gamma–G Family for Cure Fraction Models: Novel Survival Methods with Applications to Cancer Data
Cynthia A.V. Tojeiro
,Vera D. Tomazella
,Agatha S. Rodrigues
,Pedro R. Marinho
Posted: 08 May 2026
Composite Universal Constants Combining 2–5 Known Constants Reveal Latent Connections Between Disparate Physical Regimes and the Role of Dimensionless Constants in Systems of Units
Dimitris M. Christodoulou
,Demosthenes Kazanas
,Silas G. T. Laycock
Posted: 08 May 2026
Machine Learning-Based Multiclass Classification of Cognitive Stages Using Plasma Biomarkers, Clinical Assessments, and Genetic Features: A Repeated Nested Cross-Validation Study in ADNI with External Validation in CNTN
Jiayuan Xu
,Fumie Costen
Posted: 08 May 2026
Does Vitamin D–Binding Protein Predict Response to Vitamin D Supplementation in Term and Preterm Newborns? A Prospective Cohort Study
Burcu Cebeci
,Mehmet Emin Arvas
,Dilek Kurnaz
,Hakan Çakır
,Derya Büyükkayhan
,Murat Elevli
Background: Vitamin D–binding protein (DBP) is the principal carrier of circulating 25-hydroxyvitamin D3 [25(OH)D3] and is independently synthesized by the neonate. Whether neonatal DBP at birth adds predictive value beyond baseline 25(OH)D3 for supplementation response remains unclear. Methods: This single-center prospective cohort study enrolled 101 neonates. Neonates with 25(OH)D3 <20 ng/mL (supplementation-response cohort; n = 59: 29 preterm, 30 term) received 800 IU/day oral cholecalciferol for 8 weeks; neonates with 25(OH)D3 ≥20 ng/mL served as baseline reference controls (n = 42). Serum 25(OH)D3 and DBP were measured at baseline and week 8 in the supplementation-response cohort. Results: Median baseline 25(OH)D3 was 8.60 [6.70–12.05] ng/mL and median baseline DBP was 4.97 [3.70–8.19] µg/mL. After supplementation, 25(OH)D3 increased significantly (median Δ = 17.70 ng/mL; p <0.001), with 55/59 (93.2%) achieving sufficiency. In multivariable regression, gestational age was the strongest independent predictor of Δ25(OH)D3 (β = −0.440, p = 0.001), followed by baseline 25(OH)D3 (β = −0.314, p = 0.015); baseline DBP was not significant (β = 0.072, p = 0.551). Conclusions: Baseline DBP did not independently predict supplementation response. Lower gestational age and lower baseline 25(OH)D₃ were associated with greater increases in 25(OH)D₃ after supplementation, whereas baseline DBP provided no additional predictive value. Supplementation with 800 IU/day for 8 weeks was effective across gestational-age categories. Routine DBP measurement does not appear to provide additional clinical value for guiding neonatal vitamin D supplementation.
Background: Vitamin D–binding protein (DBP) is the principal carrier of circulating 25-hydroxyvitamin D3 [25(OH)D3] and is independently synthesized by the neonate. Whether neonatal DBP at birth adds predictive value beyond baseline 25(OH)D3 for supplementation response remains unclear. Methods: This single-center prospective cohort study enrolled 101 neonates. Neonates with 25(OH)D3 <20 ng/mL (supplementation-response cohort; n = 59: 29 preterm, 30 term) received 800 IU/day oral cholecalciferol for 8 weeks; neonates with 25(OH)D3 ≥20 ng/mL served as baseline reference controls (n = 42). Serum 25(OH)D3 and DBP were measured at baseline and week 8 in the supplementation-response cohort. Results: Median baseline 25(OH)D3 was 8.60 [6.70–12.05] ng/mL and median baseline DBP was 4.97 [3.70–8.19] µg/mL. After supplementation, 25(OH)D3 increased significantly (median Δ = 17.70 ng/mL; p <0.001), with 55/59 (93.2%) achieving sufficiency. In multivariable regression, gestational age was the strongest independent predictor of Δ25(OH)D3 (β = −0.440, p = 0.001), followed by baseline 25(OH)D3 (β = −0.314, p = 0.015); baseline DBP was not significant (β = 0.072, p = 0.551). Conclusions: Baseline DBP did not independently predict supplementation response. Lower gestational age and lower baseline 25(OH)D₃ were associated with greater increases in 25(OH)D₃ after supplementation, whereas baseline DBP provided no additional predictive value. Supplementation with 800 IU/day for 8 weeks was effective across gestational-age categories. Routine DBP measurement does not appear to provide additional clinical value for guiding neonatal vitamin D supplementation.
Posted: 08 May 2026
A Model of Cooperation Formation among States Based on a Mutual Trust
Guennady Ougolnitsky
,Anatoly Usov
Posted: 08 May 2026
Chromosomal Microarray Analysis in the Era of Optical Genome Mapping: Clinical Implications in Detecting Copy-Neutral Events
Alexander R. Marr
,Patrick R. Gonzales
,Shivani Golem
Posted: 08 May 2026
Evaluation of Four Satellite-Derived High-Resolution Operational Sea Ice Concentration Products for Determination of Marginal Ice Zones Around Svalbard
Keguang Wang
,Caixin Wang
Posted: 08 May 2026
Compaction and Pressure Solution of Mixed Mineral Assemblages: Implications for Granite Fracture Sealing in the Near-Field of High-Level Radioactive Waste Repository
Xiao Tian
,Ju Wang
,Jia-Wei Wang
,Jing-Li Xie
,Zhi-Chao Zhou
,Ke Li
Posted: 08 May 2026
Comparison of Preoperative Refractive Status and Postoperative Recovery Outcomes Following Transepithelial Photorefractive Keratectomy
Jiunn-Liang Chen
,Kai-Ling Peng
Posted: 08 May 2026
The Predictive Relationship Between Stablecoin and Cryptocurrency Returns During Periods of Intense Market Stress
Claudio Boido
,Lewin Jones
Posted: 08 May 2026
Sensitivity Analysis of Cracking Behavior in Fully Ceramic Microencapsulated Fuel
Shichao Liu
,Haoyue Huang
,Chi Chen
,Yanli Zhao
,Yuanming Li
,Chenxi Li
,Yi Zhou
Posted: 08 May 2026
RankBridge: Privacy-Preserving Rank-Based Explanation Clustering for Heterogeneous Federated Phishing Detection
Panhapiseth Lim
,Priyanka Kumar
,Richard Zanni
,Timothy Lambdin
Posted: 08 May 2026
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