Patients with chronic (CM) and high frequency episodic migraine (HFEM) report cognitive complaints that contribute to migraine burden. Although, there is little evidence about the ef-fects of migraine treatments on these symptoms. Objective: To evaluate the effect of preventive treatment on the impact of cognitive symptoms, specifically the ability to concentrate, in individuals with CM and HFEM. Methods: Prospective cohort study in patients with CM and HFEM initiating treatment with botulinum toxin (BT) or anti-CGRP/R monoclonal antibodies (mAbs). Patients were evaluated at baseline and after 3 months of treatment, using a headache diary and a question about the im-pact of migraine attacks on concentration (never, rarely, sometimes, often, and always). Results: 108 patients (105 females, 44.3 years of age on average), 75% with CM and 27% with HFEM were included, 55 received a first session of BT and 53 received 3 injections of a monthly mAb. In both groups, there was a significant decline on the impact of migraine in concentration (related samples Wilcoxon signed rank test <0.001) compared to baseline. Reduction in monthly headache days was the main predictor of any concentration improvement, while treatment group, age, ongoing medication with topiramate or baseline medication overuse were not sig-nificant. Conclusion: Preventive treatment of HFEM or CM with drugs not acting on central nervous sys-tem is associated with a decrease of the impact of migraine attacks on concentration, predicted by the decline in headache days. These results indicate that migraine preventive treatment also improves non-pain symptoms, which is relevant given the contribution of cognitive complaints to the impact of headache attacks

Purpose: This study aimed to evaluate the nanomechanical properties and chemical composition of restorative materials and dental surfaces using different toothpastes. Methods: Enamel (n=60) and dentin (n=60) bovine blocks were obtained and restored using resin-modified glass ionomer cement (RMGIC, n=30) or composite resin (CR, n=30) to form the dentin adjacent to RMGIC (DRMGIC), enamel adjacent to RMGIC (ERMGIC), dentin adjacent to CR (DCR), and enamel adjacent to CR (ECR). After restoration, one hemiface of each specimen was coated with an acid-resistant varnish to create the control (C) and eroded (E) sides (erosion: 5 days, 4 × 2 min/day; 1% citric acid / abrasion: 2 × 15 s followed by immersion on slurries 2 min). Three toothpastes were used: without fluoride (WF; n=10), sodium fluoride (NaF; n=10), and stannous fluoride (SnF2; n=10). The specimens were analyzed for nanohardness (H), elastic modulus (Er), and chemical composition using energy-dispersive X-ray spectroscopy (EDS) and Raman microscopy. Data were analyzed using ANOVA two-way repeated measures and Tukey’s test (α = 0.05). Results: The NaF presented lower values of H for DRMGIC-C, with a statistical difference for WF (p < 0.05). SnF2 resulted in lower Er values for ERMGIC-E and RMGIC-E than WF and NaF (p < 0.05). WF showed lower calcium and phosphorus concentrations for DCR-E than other types of toothpastes (p < 0.05). Only stannous-based toothpaste damaged the elasticity of eroded glass ionomer restorations performed in enamel. Toothpastes with fluoride was capable for maintaining main chemical elements of dentin adjacent to restorative materials under challenge conditions.