Meditation is a practice that involves focusing the mind, typically with the aim of achieving a state of mental clarity, relaxation, and heightened awareness. This review delves into the question of why we need to look into individual differences in the neurophysiology of meditators. While the neuroscientific research conducted over the past 50 years has given us remarkable insights on what happens to the brain before, during, and after meditative practices, much of the research has focused on the “average” effects as seen in controls and meditators. However, the individual variations caused by cognitive abilities, personality traits, attention span, and emotional regulation skills have been understudied. Integrating neuroimaging research with psychology leads to the examination of how meditation influences brain activity and structure while highlighting individual differences in traits like neuroticism and mindfulness. The key motivation for this review lies in the fact that personality, attention, and cognitive mechanisms, among several other factors, are highly variable among individuals. The findings suggest that meditation has broader psychological, physiological, and neurological effects than previously thought, and underscores the need for further interdisciplinary research on its long-term and varying impact on mental health and well-being.