Feline pseudomembranous cystitis (PMC) is an infrequent condition characterized by acute urinary disturbances. This study examines the diagnostic criteria, surgical interventions, and postoperative management strategies to furnish clinical guidance. A retrospective analysis was conducted on the clinical data of a 3-year-old neutered male golden tabby cat (weighing 4 kg) presenting with acute urinary retention. The diagnosis of PMC was established through clinical manifestations, abdominal ultrasonography, and laboratory tests, followed by cystotomy and targeted postoperative management. The surgical procedure lasted one hour with a blood loss of 5 mL, and spontaneous urination resumed by the fourth postoperative day. Ultrasound examination on the twelfth day revealed normal bladder mucosa, and the infection had resolved without recurrence during the follow-up period. Cystotomy with complete pseudomembrane removal effectively treats severe feline pseudomembranous cystitis. Careful preoperative assessment, precise surgery, and postoperative treatment guided by drug sensitivity greatly reduce risks and enhance outcomes. Key to recovery are thorough pseudomembrane removal and proper bladder irrigation.