Submitted:
24 April 2026
Posted:
27 April 2026
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Abstract
This study supports the use of human skin explants as a versatile and translational model for evaluating pharmacologic skin responses and topical bioactivity. The approach allows mechanistic insight beyond single biomarkers and may serve as a scalable pharmacologic platform for efficacy testing, particularly when expanded to include multiple donors and broader readouts.
Keywords:
ex vivo model
; pharmacological evaluation
; skin pharmacology
; natural product pharmacology
; inflammatory response
; topical delivery
; preclinical evaluation
; drug screening platform
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