This study evaluates the effects of Al2O3 and CeO2 nanoparticles as additives to standard diesel and biodiesel fuels on the combustion and emissions characteristics of a CR diesel engine with split injection (pilot and main injections). Three nanoparticle dosing levels (50 ppm, 100 ppm, and 150 ppm) were compared with undoped standard diesel and bio-diesel fuels. The results showed that the presence of both Al2O3 and CeO2 in biodiesel in-creased the ignition delay of the pilot fuel by about 8.0% at low load and about 3.5% at high load. The addition of both nanoparticles to diesel and biodiesel fuels had an insig-nificant effect on the main injection fuel's ignition delay, MBF50 position and combustion duration. The thermal efficiency was up to 1.0% lower. Al2O3 additive in diesel had no significant effect on NOx emissions. CO emissions were higher by 4.4-7.5% in most cases. The Al2O3 additive in biodiesel reduced NOx emissions by an average of 38%, 17.1%, and 9.4% at low, medium, and high engine loads, respectively. The reduction in CO emissions was on average 15%. The addition of CeO₂ nanoparticles to diesel fuel reduced NOₓ emis-sions by 22.5%, 8.5%, and 3.1% on average at low, medium, and high engine loads, re-spectively. When the engine was operated on CeO₂ doped biodiesel, NOₓ emissions were lower by an average of 25.7%, 9.6%, and 2.5% at low, medium, and high loads, respective-ly. Adding CeO₂ nanoparticles to diesel fuel increased CO emissions, whereas adding them to biodiesel significantly reduced CO emissions.