Preprint
Review

This version is not peer-reviewed.

Personalized Nutrition, Lifestyle, and Supplementation Strategies to Support Cognitive Performance and Well-Being in Esports Athletes: A Narrative Review

A peer-reviewed version of this preprint was published in:
Nutrients 2026, 18(6), 981. https://doi.org/10.3390/nu18060981

Submitted:

23 February 2026

Posted:

25 February 2026

You are already at the latest version

Abstract
Esports are a rapidly expanding form of competitive activity that demand high levels of cognitive alertness, motor precision, stress management, and resilience to mental and physical fatigue. At the same time, the sedentary lifestyle, extended screen exposure, and psychological pressures associated with competitive gaming raise concerns for both performance and long-term health. Growing evidence highlights the importance of nutrition and lifestyle behaviors in supporting cognitive performance and overall competitive demands. While balanced dietary patterns and adequate hydration are essential, dietary supplements may provide additional benefits when used appropriately and under professional guidance. However, the current research is limited by a predominance of cross-sectional and self-reported studies, short-term or acute interventions, small sample sizes, and insufficient emphasis on esports-specific and personalized strategies. This review examines existing evidence on individualized nutrition, supplementation, and lifestyle strategies in esports, identifies key methodological limitations, and outlines future directions to inform evidence-based practice for athletes, practitioners, and organizations seeking to optimize cognitive performance, well-being, and long-term sustainability in this emerging field.
Keywords: 
;  ;  ;  ;  ;  ;  

1. Introduction

Esports, or competitive video gaming, have evolved from a leisure activity into a structured and professionalized part of the global sports and entertainment industry. The global esports market is projected to reach approximately USD 4.5 billion by 2026, and audiences are forecasted to continue growing toward around 900 million users in the coming years, indicating its widening global reach [1,2]. This expanding cultural and economic influence is further reflected by high-profile institutional recognition. In January 2026, six-time League of Legends world champion Lee “Faker” Sang-hyeok was awarded the Cheongyeong Medal by the President of South Korea, marking the first time an esports athlete has received the country’s highest sporting honor and symbolizing broader acceptance of esports within national sports cultures [3]. At the international level, the International Olympic Committee has explored integrating esports into the Olympic Movement, including announcing plans for an “Olympic Esports Games” in partnership with the Saudi Olympic and Paralympic Committee. While a 2027 event in Riyadh was initially discussed, the collaboration was later discontinued, and the IOC has stated that it intends to pursue a revised approach without a confirmed host or date at this time [4]. Together, these developments highlight how esports now rival certain traditional sports in both global influence and institutional validation.
Despite being virtual in nature, esports impose substantial demands on athletes. Success in competition requires sustained cognitive alertness, precise motor coordination, rapid decision-making under pressure, and resilience to mental and physical fatigue [7,8]. Concurrently, the lifestyle associated with esports, characterized by physical inactivity, extended screen time, disrupted sleep cycles, and high psychological stress, poses risks to both short and long-term health [5,6]. These challenges highlight the need for tailored strategies that not only optimize in-game performance but also safeguard athlete well-being [5,6,7,8].
Emerging evidence suggests that nutrition, dietary supplementation, and lifestyle habits play a crucial role in shaping both cognitive and physical performance in esports athletes [5]. Balanced dietary patterns, adequate hydration, and sufficient sleep are consistently linked to improved mental clarity, reaction times, and stress management [5,6]. Similarly, targeted use of supplements and structured physical activity have been proposed as means to counteract fatigue, musculoskeletal strain, and mental burnout [9,10,11]. However, most existing studies remain limited in scope, relying on self-reports, short-term interventions, or non-standardized measures, while personalized approaches remain scarce [5,9,10,11,12].
Specifically, much of the existing literature frequently borrows frameworks from traditional sports without esports-specific validation, prioritizes acute supplementation outcomes over long-term adaptations, and rarely considers individualized nutrition or interactions with broader lifestyle factors such as sleep, stress, and physical activity.
This review seeks to address these gaps by examining the significance of individualized nutrition, supplementation, and lifestyle practices in esports. By consolidating recent findings, it aims to provide an overview of existing knowledge, highlight key methodological limitations, and propose directions for future research. Furthermore, it evaluates the emerging role of digital and AI-driven tools for individualized monitoring and intervention, while addressing the ethical and practical risks associated with their implementation in esports. In doing so, it underlines the importance of approaching esports not merely as a form of digital entertainment, but as a demanding competitive field that requires the same level of scientific attention as traditional sports.

2. Review Design and Literature Search Strategy

This narrative review was informed by a structured literature search conducted across PubMed, Scopus, and Web of Science. The search covered publications from 2005 to 2025 and combined terms related to “esports” or “competitive gaming” with “nutrition,” “dietary supplements,” “cognition,” “lifestyle behaviors,” “physical activity,” “sleep,” and “performance.”
Eligible studies included peer-reviewed publications in English involving human participants engaged in esports or competitive gaming. The population of interest comprised adolescent and adult esports players, competitive gamers, and elite esports athletes. Both professional and amateur competitors were considered.
A range of study designs was included, reflecting the emerging nature of the field. These comprised cross-sectional studies, cohort studies, randomized controlled trials, experimental laboratory studies, intervention studies, and relevant systematic reviews. Where esports-specific evidence was limited, mechanistic or comparative studies conducted in traditional athletic or cognitive-performance populations were included to contextualize findings.
Exclusion criteria included studies focusing exclusively on non-competitive gaming, pediatric or clinical populations unrelated to esports performance, non-human studies, conference abstracts, commentaries, and non-peer-reviewed sources.
After screening titles, abstracts, and full texts for relevance and eligibility, a total of 52 studies were included in the final synthesis. Of these, 17 primary empirical studies are summarized in Table 1, representing observational, experimental, and randomized controlled designs.
Given the developing state of esports research, this review aimed to provide a comprehensive and critical synthesis of current evidence rather than a formal systematic or meta-analytic evaluation.

3. Psychophysical Health and Lifestyle Behaviors

Research on esports athletes increasingly highlights the close relationship between lifestyle habits, physical health, and psychological well-being. Several studies indicate that higher levels of gaming involvement are not necessarily associated with poorer health outcomes [13]. In fact, elite players often display better physical activity profiles than lower-ranked athletes [13]. Despite long training hours, top-level competitors were found to engage in more frequent exercise and report better overall health compared to their lower-ranked peers, though only a minority (19.7%) met the World Health Organization’s guidelines for physical activity [13,15]. At the same time, the prevalence of overweight and obesity, alongside a substantial proportion of players classified as normal weight, suggests the need for structured exercise interventions to support both health and long-term performance capacity [13,14,15].
From a physiological perspective, esports present a dual challenge: competitive gameplay elicits acute physiological stress, while the broader training context is characterized by prolonged sedentary exposure. In controlled experiments, elite players demonstrated significant increases in energy expenditure, oxygen consumption, and heart rate during gameplay, comparable to moderate-intensity physical activity [16,17,18]. However, prolonged sedentary postures remain a major concern. Evidence suggests that esports athletes are prone to fatigue, musculoskeletal discomfort, headaches, and visual strain, particularly after extended sessions, underscoring the need to balance performance demands with preventive health strategies related to posture, movement, and recovery to maintain training consistency and competitive readiness [11,13,14].
Beyond the physical domain, psychological and behavioral factors act as important performance modifiers. Anxiety, depression, poor sleep quality, and unhealthy dietary patterns are commonly reported in esports populations, with nearly one-quarter of players experiencing depressive symptoms and almost half reporting sleep disturbances [19]. Coping strategies were shown to significantly influence these outcomes: dysfunctional coping was associated with higher alcohol consumption, sleep disorders, and increased anxiety, whereas adaptive strategies served a protective role [19]. The role of stress was further emphasized in physiological studies, which documented cardiovascular and metabolic responses during competition, reflecting the high psychological intensity of esports and its potential impact on performance stability [7,18,20].
Within this context, targeted interventions aimed at cognitive and psychophysical resilience may offer meaningful benefits. Short-term programs using virtual reality (VR) have demonstrated improvements in visuomotor coordination, accuracy, and reaction time, with effects persisting up to one month post-intervention [21].
Finally, lifestyle behaviors extend to sensory health. Excessive exposure to loud in-game audio is linked to symptoms of hearing strain, tinnitus, and perceived ear pressure, despite widespread awareness of these risks among players [22]. Still, only a small minority adopt protective practices such as regular breaks or volume adjustments, highlighting the need for health education and prevention strategies to preserve sensory function essential for sustained competitive engagement [22]. Overall, current evidence suggests that optimizing lifestyle behaviors and preventive health strategies may be critical for maintaining both performance and long-term well-being in esports athletes.

4. Nutrition and Cognitive and Physiological Function

4.1. Macronutrients and Micronutrients

Nutrition is widely recognized as a cornerstone of athletic performance, yet in esports its role remains comparatively underexplored. Although awareness of its importance is increasing, current evidence suggests that many esports athletes adopt dietary patterns that fall short of supporting their cognitive and physical demands [5,9,23]. It is important to note that much of the available evidence is derived from cross-sectional or self-reported studies and short-term interventions. Readers should therefore interpret associations cautiously while considering the need for more controlled, esports-specific research. Several studies have shown that inadequate nutrition, whether through meal skipping, insufficient daily caloric intake, or reliance on processed foods with limited consumption of fruits and vegetables, may undermine both performance and long-term health outcomes [23,24].
From a physiological perspective, carbohydrates represent the primary energy substrate for the brain and central nervous system, and insufficient carbohydrate availability or poorly timed intake may contribute to mental fatigue, impaired attention, and slower reaction speed during extended periods of gameplay [5].
Protein intake also plays a dual role in esports. Beyond its established importance for muscle maintenance and recovery, sufficient protein consumption has been associated with improved cognitive performance, possibly through effects on neurotransmitter synthesis and satiety regulation [5]. In contrast, dietary fat quality appears more relevant than total fat intake. Diets high in saturated fats and low in unsaturated fatty acids are associated with poorer cardiometabolic profiles and may negatively influence cognitive flexibility, whereas diets rich in unsaturated fats, particularly omega-3 fatty acids, support brain cell structure and neurovascular function [25].
At the same time, research points to a positive association between micronutrients and enhanced cognitive performance in esports. Goulart et al. (2023), for example, identified significant correlations between intake of magnesium, zinc, selenium, B vitamins, omega-3 and omega-6 fatty acids, and choline, with improved results in cognitive training tasks [5]. These findings are in line with broader evidence showing the role of micronutrients and polyunsaturated fatty acids in supporting executive function, reaction time, and neural resilience [26]. Moreover, antioxidant-rich foods, such as vegetables, were linked to greater attentional performance, likely through reductions in oxidative stress and inflammation [5,25,26].

4.2. Dietary Patterns

Rather than isolated nutrients, overall dietary patterns appear to influence both cognitive and physiological health. Observational studies from Portugal, Brazil, Poland, and Germany report dietary behaviors among esports athletes characterized by frequent consumption of fast foods, sugary beverages, and energy drinks, alongside low intake of fruits, vegetables, and fish [9,10,25]. In several of these studies, adherence to Mediterranean-style dietary patterns was assessed as an index of diet quality and was generally reported to be low. These patterns mirror a Westernized dietary model, characterized by high intakes of sugar, sodium, and saturated fat, and low intakes in fiber and micronutrients, which are associated with increased risks of obesity, metabolic disease, and impaired cognitive function.
Ribeiro et al. (2023) reported that greater adherence to the Mediterranean diet is associated with better diet quality, lower cardiometabolic risk, and healthier lifestyle patterns, suggesting potential relevance for esports populations [25]. In a comparative study by Alkan et al. (2025), university esports players and non-esports peers demonstrated that esports participants exhibited poorer overall dietary quality and less favorable lifestyle profiles, reinforcing concerns about the long-term health implications of prevailing dietary patterns not fully aligned with Mediterranean principles [23].
More broadly, evidence suggests that esports athletes frequently adopt irregular eating patterns and do not meet total energy intake requirements, raising concerns about their capacity to sustain performance across repeated training and competitive schedules [5,9,23].

4.3. Mental Health and Nutrition

Importantly, the consequences of these patterns extend beyond physical health. Soffner et al. (2023) specifically noted that despite reporting positive self-rated health, many players displayed elevated BMI, physical inactivity, and reliance on convenience foods and energy drinks, with implications for both mental well-being and performance. Furthermore, Arslan et al. (2024) reported that more than one in five esports athletes displayed signs of food addiction, and over 13% reported night eating syndrome. Risk factors included meal skipping, longer gaming hours, and poor sleep quality, behaviors that are closely tied to esports’ unique demands and schedules. In combination, these findings underscore that nutrition is not only a matter of fueling performance but also a matter of protecting mental health and preventing maladaptive coping mechanisms [9,27].
From a biological standpoint, emerging evidence highlights the relevance of the gut–brain axis. Kulecka et al. (2023) observed reduced microbial diversity and lower concentrations of short-chain fatty acids in esports players compared to endurance athletes [24]. Such differences could have important implications, given the established gut–brain axis and its proposed influence on cognition, mood, and inflammation, although current evidence in esports remains largely associative. These insights point toward nutrition not only as behavioral input but also as a biological modulator of performance and resilience. Beyond cognitive effects, reduced microbial diversity and lower short-chain fatty acid production have been associated with impaired metabolic efficiency and inflammatory control in other athletic and clinical populations, and may therefore represent plausible mechanisms influencing fatigue tolerance and recovery capacity in esports athletes [24].

4.4. Dietary Supplements

Dietary supplements are increasingly discussed within esports communities, particularly in the form of ergogenic or cognitive-enhancing products. In contrast to traditional sports, where supplementation often targets strength or endurance, esports-related supplementation strategies primarily aim to enhance cognitive performance, reaction speed, vigilance, and resistance to mental fatigue [28,30,32]. Among the compounds investigated to date, caffeine represents the most consistently substantiated supplement, supported by multiple randomized controlled trials in gaming contexts. Amino acid–based formulations show promising but still preliminary evidence, whereas creatine and plant-derived bioactives remain emerging areas of investigation. The following section synthesizes the evidence according to its relative strength.

4.5. Caffeine

Among all supplements, caffeine remains the most consistently studied and has been shown to enhance multiple domains of cognitive function, including reaction time, sustained attention, and alertness, largely through antagonism of adenosine receptors and modulation of central nervous system arousal [33,34]. These effects have also been demonstrated in gaming and esports contexts. Several randomized controlled trials in esports athletes report improvements in reaction time, aiming accuracy, vigilance, and overall gaming performance following acute caffeine ingestion [31,34]. However, studies also highlight potential downsides, including increased anxiety, sleep disturbances, and cardiovascular strain, particularly when consumed in high doses or late in the day [33,34].

4.6. Amino Acids

Amino acid supplementation has shown promising but preliminary results. Both arginine and inositol have been linked to improvements in cognitive control and processing efficiency [29,30,31]. Tartar et al. (2019) reported enhanced accuracy and reduced impulsivity following arginine supplementation, while Sowinski et al. (2021) found improvements in attentional control with inositol. While the present evidence focuses on isolated amino acid supplementation, adequate dietary protein remains a prerequisite for optimal neurotransmitter synthesis and may influence responsiveness to supplementation. [30]. These findings suggest that protein intake and amino acid availability may support the cognitive demands of esports, though current evidence remains limited to short interventions and small cohorts [30,31,32].

4.7. Creatine

Creatine, traditionally recognized for its role in high-intensity physical performance, has recently attracted interest for its potential cognitive benefits, particularly in tasks requiring rapid information processing and executive control. Preliminary evidence in esports populations suggests that short-term creatine supplementation may improve reaction time, attention, and in-game performance metrics [35]. Beyond esports-specific research, a broader body of literature in healthy adults suggests that creatine supplementation may support aspects of cognitive performance, particularly under conditions of high mental demand, sleep deprivation, or fatigue, supporting its potential relevance in prolonged gaming contexts [36]. These findings are biologically plausible, given creatine’s role in cerebral energy metabolism and ATP resynthesis, which may be particularly relevant during prolonged cognitively demanding gameplay [37]. However, larger randomized controlled trials are required to confirm efficacy and establish optimal dosing strategies within esports settings.

4.7. Herbs and Plant-Derived Bioactives

Interest has also expanded into plant-derived compounds and novel supplements. Mangifera indica extract has been associated with improved working memory and reduced mental fatigue, while lutein, a carotenoid with neuroprotective properties, has been linked to better visual processing speed and accuracy [38,39]. Similarly, beetroot-derived nitrates, widely studied in traditional sports, may hold relevance for esports by enhancing cerebral blood flow, endothelial function, and oxygen efficiency, mechanisms that could support sustained attention and cognitive endurance during prolonged gameplay [40,41]. Polyphenol-rich compounds, such as cocoa flavanols and berry extracts, have demonstrated short-term benefits for attention and executive function in cognitively demanding tasks, potentially offering further support against mental fatigue [42,43]. However, plant-derived supplements may present additional considerations related to product standardization and contamination risk. Variability in bioactive content and the potential presence of undeclared stimulant compounds have been reported in certain commercial products, raising concerns regarding quality control and regulatory oversight. In competitive settings, such inconsistencies may pose both health risks and inadvertent doping concerns, underscoring the importance of third-party testing and cautious integration of plant-derived supplements into esports performance strategies [40,41,42,43].
Table 2. Summary of Dietary Supplements, Proposed Mechanisms, and Strength of Evidence for Cognitive Performance in Esports.
Table 2. Summary of Dietary Supplements, Proposed Mechanisms, and Strength of Evidence for Cognitive Performance in Esports.
Supplement Proposed Mechanism Primary Effect (s) Level of Evidence Key Considerations
Caffeine Adenosine receptor antagonism; Increase CNS arousal Improved reaction time, sustained attention, vigilance, aiming accuracy [31,33,34] High Anxiety, sleep disruption, dose timing; critical requires individualized dosing.
Arginine Nitric oxide pathway; possible neurovascular effects Improved accuracy, reduced impulsivity [29,30,31,32] Moderate Small samples; short duration
Inositol Modulation of neurotransmitter signaling Improved attentional control [29,30,31,32] Moderate Limited replication
Creatine Monohydrate Enhanced cerebral ATP resynthesis; energy buffering Improved processing speed and executive function [35,36,37] Emerging Dose-response unclear; larger RCTs needed
Mangifera indica extract Polyphenol activity; anti-fatigue mechanisms Improved working memory, reduced mental fatigue [38] Emerging Product standardization variability and potential contamination risks
Lutein Neuroprotective carotenoid; visual processing support Improved visual processing speed and contrast sensitivity [39] Emerging Long-term intake required; specifically relevant for eye health
Beetroot-derived nitrates Increase cerebral blood flow; endothelial function Potential support for sustained attention, cerebral blood flow, oxygen efficiency [40,41] Low/Extrapolated Mechanism plausible; limited esports trials
Polyphenol-rich compounds (coca, berries) Antioxidant; improved cerebral perfusion Short-term improvements in attention and executive function [42,43] Low/Preliminary Variability in dosing and bioactive content
Note: CNS” central nervous system; ATP = adenosine triphosphate; RCTs = randomized controlled trials. Evidence levels reflect the relative strength and consistency of available esports-specific research: High = multiple RCTs in gaming/esports populations; Moderate = limited esports studies or consistent evidence in related cognitive domains; Emerging = preliminary esports data or strong biological plausibility; Low/Extrapolated = derived primarily from non-esports populations; Low/Preliminary = small pilot studies with substantial methodological limitations.

5. Discussion

The findings of this review emphasize the central role of nutrition, supplementation, and lifestyle behaviors in shaping both performance and health among esports athletes. A consistent theme across studies is the contrast between the physiological and cognitive demands of competitive gaming and the often suboptimal habits adopted by players. While elite competitors tend to report higher engagement in physical activity and greater awareness of health risks, the broader esports population frequently displays sedentary habits, disrupted sleep, and reliance on processed foods and energy drinks [11,23]. This duality highlights the paradox of esports: where performance optimization is often pursued through acute strategies such as caffeine or extended training, while foundational practices such as diet quality, sleep, and recovery receive less systematic attention.
Nutritionally, the body of evidence indicates that both macronutrient and micronutrient intake play a meaningful role in shaping cognitive and physiological outcomes in esports athletes. Carbohydrates serve as the primary substrate for brain energy metabolism and appear important for maintaining attention and reaction speed during prolonged gameplay, while adequate protein intake supports neurotransmitter synthesis, satiety, and post-session recovery [45]. Fat quality, rather than total fat intake, also appears relevant, with unsaturated fats, particularly omega-3 fatty acids, linked to more favorable cognitive and cardiometabolic profiles [5,24,25]. Rather than any single nutrient being decisive, these findings collectively suggest that inadequate energy availability and poor diet quality may compromise fatigue resistance, recovery capacity, and performance consistency across training and competition. Given the cognitive demands of esports, personalized nutrition strategies may be warranted. Timing of carbohydrate intake (e.g., differentiation between competition and training days), inter-individual variability in sleep chronotype and stress reactivity, and cultural or geographic dietary constraints should be considered when developing applied nutrition frameworks for esports athletes.
Beyond nutrients and energy requirements, dietary patterns and underlying biological mechanisms provide additional insight. Mediterranean-style eating patterns, characterized by high intakes of fruits, vegetables, whole grains, fish, olive oil, and nuts, are consistently linked to better cardiometabolic profiles and cognitive outcomes and may represent a practical nutritional framework for esports populations [25,46]. In parallel, emerging research on the gut–brain axis suggests that reduced microbial diversity and lower short-chain fatty acid production observed in esports players may influence cognition, mood, inflammation, and fatigue tolerance, although evidence in esports remains largely associative [22,47]. Evidence relevance may also extend beyond short-term performance and toward long-term career sustainability. Given the sedentary nature of esports training and the early age at which many players enter competitive circuits, suboptimal dietary patterns and insufficient total energy intake increase the risk of non-communicable diseases, including obesity, metabolic syndrome, and cardiovascular dysfunction, which can impair both health and sustained competitive capacity [23].
Supplementation research offers cautious optimism but remains constrained. Although caffeine demonstrates the most reliable short-term performance benefits in esports contexts, its habitual use warrants careful consideration. Individual sensitivity, sleep quality, competition timing, and long-term health implications should inform its integration into structured training routines. [28,30,33,34]. Creatine monohydrate may represent a promising adjunct given its role in cerebral energy metabolism and preliminary findings suggesting improvements in reaction time and executive function [35,36,37]. Amino acids such as arginine and inositol show preliminary benefits for attention and processing efficiency, while plant-derived, nitrate-rich compounds and polyphenol-rich sources represent emerging areas of interest [38,40,41,42,43]. Overall, supplements appear most effective when integrated within optimized nutrition, sleep, and structured training frameworks rather than used as standalone performance strategies. Interpretation of current findings is further complicated by insufficient control of confounding lifestyle variables, including diet quality, sleep, stress load, and physical activity.
Lifestyle factors remain critical for performance sustainability. Sleep quality, stress management, and coping strategies are consistently identified as determinants of both psychological resilience and competitive success [19]. Promising interventions, such as structured physical conditioning, cognitive training, and health education programs, have shown effectiveness in reducing fatigue and enhancing focus, yet their uptake in professional practice remains limited [48,49].
Beyond traditional approaches, digital health technologies and artificial intelligence (AI) tools offer significant potential for personalized monitoring of diet, sleep, stress, and performance metrics in esports [50]. AI-driven platforms could facilitate adaptive interventions by integrating wearable sensor data and nutritional tracking systems [51]. However, validation in esports populations remains limited, and ethical considerations, including data privacy, algorithmic bias, and over-reliance on automated decision-making, require careful attention. AI should therefore be positioned as a decision-support tool designed to augment, rather than replace, professional oversight by credentialed practitioners.
Collectively, the available evidence suggests that nutrition, supplementation, and lifestyle behaviors operate as interconnected determinants of performance and health in esports. Performance optimization in this context appears to depend less on isolated interventions and more on the integration of dietary adequacy, recovery practices, structured training, and individualized support within a coherent performance framework [44].

6. Conclusion

This narrative review highlights the complex and multifaceted demands placed on esports athletes and underscores the central role of nutrition, supplementation, and lifestyle behaviors in supporting both performance and long-term health. Although esports are frequently conceptualized as predominantly cognitive activities, the evidence demonstrates that competitive gaming imposes meaningful physiological, psychological, and metabolic challenges that require structured and evidence-informed management.
Inadequate dietary patterns, irregular energy intake, and suboptimal lifestyle behaviors remain prevalent among esports athletes, potentially undermining cognitive endurance, stress tolerance, and overall well-being. Conversely, balanced dietary patterns characterized by sufficient energy availability, high-quality macronutrient distribution, and adequate micronutrient intake appear to support executive function, metabolic resilience, and performance consistency. While selected dietary supplements, including caffeine and certain amino acids, may offer targeted situational benefits, their effectiveness is best understood within the broader context of optimized foundational health behaviors rather than as standalone performance solutions.
Practical implications follow that teams and practitioners should prioritize comprehensive baseline screening including diet quality, energy intake, sleep patterns, and disordered eating risk, incorporate credentialed nutrition and health professionals within multidisciplinary support structures, and promote structured physical conditioning and sleep hygiene practices. Supplementation and emerging technologies should be introduced only after these foundations are in place, used selectively, and monitored within evidence-based frameworks. Interventions should be personalized, considering factors such as metabolism, circadian timing, stress load, and competition demands, and evaluated in ecologically valid training and match environments.
As esports continues to mature into a rigorous professional discipline, its long-term success will depend less on acute performance fixes and more on the adoption of structured, health-centered support systems that align competitive ambition with sustainable well-being. Embedding personalized nutrition, lifestyle management, and evidence-based supplementation within professional practice, complemented by disciplined training, structured recovery, and consistent performance development, creates a holistic framework that strengthens physiological resilience, optimizes cognitive performance, and promotes career longevity. By moving beyond a “game-only” focus, this approach positions health not as a secondary consideration, but as a foundational pillar of competitive excellence in the modern esports era.

7. Limitations and Future Research Directions

The current body of evidence in esports nutrition and supplementation is characterized by several methodological constraints. Many studies rely on cross-sectional designs, self-reported dietary and lifestyle measures, small sample sizes, and short intervention periods, limiting the ability to establish causal relationships and increasing the risk of bias. Specifically, it remains unclear whether healthy dietary patterns directly enhance cognitive performance or whether athletes with higher baseline cognitive abilities naturally adopt healthier habits. Moreover, confounding factors, such as sleep quality, stress load, physical activity, and training volume, are inconsistently controlled, complicating interpretation of observed associations.
To strengthen the evidence base, future research must prioritize longitudinal, well-powered intervention trials conducted in ecologically valid esports environments. Studies should assess both acute and chronic effects of nutrition and supplementation on cognitive performance, recovery, metabolic health, and markers of career longevity. Incorporating objective biomarkers, physiological measures, and standardized performance metrics will clarify underlying mechanisms of action and improve reproducibility. Greater attention should also be directed to personalization, considering timing strategies for training versus competition and cultural or geographic dietary constraints, while integrating nutritional interventions with holistic approaches to athlete health.
Beyond methodology, several practical and regulatory considerations regarding supplements, remain under addressed in esports. Unlike traditional sports, esports currently lack standardized supplement guidelines, clear anti-doping frameworks, and consistent oversight [52].The variability in supplement quality and the risk of contamination with undeclared substances represent major concerns, particularly given the widespread use of energy drinks, nootropic blends, and commercially marketed performance products [52]. Strengthening quality assurance practices, promoting third-party testing, and clarifying governance structures are essential steps toward minimizing health risks and inadvertent rule violations within competitive settings [52].
Collectively, advancing the field will require methodological rigor, interdisciplinary collaboration, and the development of esports-specific guidelines that translate emerging evidence into safe, practical, and sustainable applications.

8. Key Takeaways for Practitioners

  • Prioritize nutritional foundations before supplementation.
Adequate total energy intake, macronutrient balance, and micronutrient sufficiency should form the basis of performance support. Strategic meal planning should reflect training load and competition schedules (e.g., training vs. rest days, match days vs. off days) to sustain cognitive endurance, recovery, and consistency. Supplements should be used selectively, monitored carefully, and only to address specific needs rather than as primary performance solutions.
  • Use supplementation as a targeted, individualized tool.
Evidence supports short-term benefits of certain supplements (e.g., caffeine, selected amino acids, plant-derived compounds), but responses vary widely. Practitioners should individualize dosing and timing, consider sleep sensitivity and stress load, and regularly reassess necessity rather than relying on habitual use.
  • Protect sleep as a non-negotiable performance resource.
Sleep quality and regularity are central to reaction time, decision-making, emotional regulation, and learning. Interventions such as sleep scheduling, light exposure management, caffeine timing, and competition-aware sleep strategies can substantially enhance performance without increasing training volume.
  • Integrate structured physical conditioning and ergonomics into daily routines.
Strength training, mobility work, and postural interventions support injury prevention, fatigue resistance, and physiological resilience. Ergonomic optimization (seating, screen height, breaks, audio exposure) should be treated as part of performance preparation, not as optional health add-ons.
  • Address stress management and coping skills explicitly.
Psychological stress is inherent to competitive gaming and directly influences cognitive performance. Teaching adaptive coping strategies, recovery routines, and emotional regulation skills can reduce burnout risk and improve performance stability under pressure.
  • Adopt a holistic, player-centered support model.
Performance staff and coaches should look beyond a game-only focus and consider the athlete behind the screen. Behaviors outside formal training, such as nutrition, sleep, recovery, stress, and daily routines, meaningfully shape in-game efficiency, learning capacity, and long-term development.
  • Recognize that performance gains do not always come from more gameplay.
Improvements in nutrition, sleep, physical conditioning, and mental recovery can enhance focus, reaction speed, and decision-making, often more efficiently than additional hours of play.
  • Embrace personalization as a core principle.
Individual variability in metabolism, chronotype, stress tolerance, and competition demands means that standardized approaches are unlikely to be optimal. Personalized, adaptable strategies represent the most effective path forward for sustainable esports performance support.

Author Contributions

Conceptualization, E.H. and L.G.; literature search and data curation, L.G.; writing—original draft preparation, L.G.; writing—review and editing, E.H., I.P.T., K.G. and A.B.; supervision, E.H. All authors have read and agreed to the published version of the manuscript.

Institutional Review Board Statement

Not applicable.

Data Availability Statement

No new data were created or analyzed in this study. Data sharing is not applicable to this article.

Conflict of Interest

The authors declare no conflict of interest.

References

  1. Future Market Insights, 2026. Esports market trends & innovations 2026–2036. 2 January 2026. Available online: https://www.futuremarketinsights.com/reports/esports-market.
  2. Quantumrun Foresight Global esports revenue and audience projections. 2025. Available online: https://www.quantumrun.com/consulting/global-esports-revenue-projections (accessed on 2 January 2026).
  3. Esports Insider. Faker awarded Cheongyeong Medal by President of South Korea. 2026. Available online: https://esportsinsider.com/2026/01/faker-cheongyeong-medal-award (accessed on 2 January 2026).
  4. International Olympic Committee. IOC Statement on the Olympic Esports Games. 2025. Available online: https://www.olympics.com/ioc/news/ioc-statement-on-the-olympic-esports-games (accessed on 3 January 2025).
  5. Goulart, B.J.; Aitken, S.J.; Siddiqui, S.; Cuevas, M.; Cardenas, J.; Beathard, M.K.; Riechman, E.S. Nutrition, lifestyle, and cognitive performance in esport athletes. Frontiers in Nutrition. 2023, 10, 1–12. [Google Scholar] [CrossRef] [PubMed]
  6. Lewis, L.D. The interconnected causes and consequences of sleep in the brain. Science 2021, 374, 564–568. [Google Scholar] [CrossRef] [PubMed]
  7. Ramirez, P.I.; Musculus, L.; Raab, M.; Laborde, S. Setting the Scientific Stage for Esports Psychology: A Systematic Review. International Review of Sport and Exercise Psychology. 2020, 13, 1–66. [Google Scholar] [CrossRef]
  8. Szot, M.; Galka, K.E.; Drozdz, R.; Fraczek, B. Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports? Healthcare 2022, 10, 1–42. [Google Scholar] [CrossRef]
  9. Soffner, M.; Bickmann, P.; Tholl, C.; Frobose, I. Dietary behavior of video game players and esports players in Germany: a cross-sectional study. Journal of Health, Population and Nutrition 2023, 42, 1–13. [Google Scholar] [CrossRef]
  10. Szot, M.; Fraczek, B.; Tyrala, F. Nutrition Patterns of Polish Esports Players. Nutrients 2023, 15, 1–20. [Google Scholar] [CrossRef]
  11. Donoghue, J.D.; Balentine, J.; Schmidt, G.; Zwibel, H. Managing the health of the eSport athlete: an integrated health management model. BMJ Open Sport & Exercise Medicine 2019, 5, 1–6. [Google Scholar] [CrossRef]
  12. Baumann, A.; Mentzoni, R.A.; Erevik, E.; Pallesen, E.S. A qualitative study on Norwegian esports students' sleep, nutritional and physical activity habits and the link to health and performance. International Journal of Esports 2022, 1, 1–13. [Google Scholar]
  13. Trotter, M.G.; Coulter, T.J.; Davis, A.P.; Poulus, D.R.; Polman, R. The Association between Esports Participation, Health and Physical Activity Behaviour. International Journal of Environmental Research and Public Health 2020, 17, 1–14. [Google Scholar] [CrossRef]
  14. Lam, K.W.; Liu, R.T.; Chen, B.; Huang, X.Z.; Yi, J.; Wong, C.W.D. Health Risks and Musculoskeletal Problems of Elite Mobile Esports Players: a Cross-Sectional Descriptive Study. Sports Medicine. 2022, 8, 1–9. [Google Scholar] [CrossRef]
  15. World Health Organization. WHO guidelines on physical activity and sedentary behaviour. 2020. Available online: https://www.who.int/publications/i/item/9789240015128 (accessed on 20 May 2025).
  16. Haupt, S.; Wolf, A.; Heidenreich, H.; Schmidt, W. Energy Expenditure during eSport – A Case Report. German Journal of Sports Medicine. 2021, 72, 36–39. [Google Scholar] [CrossRef]
  17. Kocak, U.Z. Are eSports more than just sitting? A study comparing energy expenditure. Journal of Comparative Effectiveness Research 2022, 11, 1–8. [Google Scholar] [CrossRef] [PubMed]
  18. Nicholson, M.; Poulus, D.; Robergs, R.; Kelly, V.; McNulty, C. How Much Energy Do E’Athletes Use during Gameplay? Quantifying Energy Expenditure and Heart Rate Variability within E’Athletes. Sports Medicine 2024, 10, 1–13. [Google Scholar] [CrossRef] [PubMed]
  19. Pereira, A.M.; Teques, P.; Verhagen, E.; Gouttebarge, V.; Figueiredo, P.; Brito, J. Mental health symptoms in electronic football players. BMJ Open Sport & Exercise Medicine 2021, 7, 1–9. [Google Scholar] [CrossRef]
  20. Zimmer, T.R.; Haupt, S.; Heidenreich, H.; Schmidt, W. Acute Effects of Esports on the Cardiovascular System and Energy Expenditure in Amateur Esports Players. Frontiers in Sports and Active Living 2022, 4, 1–9. [Google Scholar] [CrossRef] [PubMed]
  21. Lachowicz, M.; Pawlik, A.S.; Lachowicz, A.K.; Jamro, D.; Żurek, G. Amplifying Cognitive Functions in Amateur Esports Athletes: The Impact of Short-Term Virtual Reality Training on Reaction Time, Motor Time, and Eye–Hand Coordination. Brain Sciences 2024, 14, 1–13. [Google Scholar] [CrossRef]
  22. Diviani, N.; Chadha, S.; Mulas, P.; Rubinelli, S. Safe Listening Beliefs, Attitudes, and Practices Among Gamers and Esports Participants: International Web-Based Survey. JMIR Formative Research 2025, 9, 1–15. [Google Scholar] [CrossRef]
  23. Alkan, S.B.; Ağar, K.; Kaşikçi, H. Comparative analysis of dietary habits and lifestyles between esports players and non-esports players among university students. British Journal of Nutrition 2025, 24, 1–18. [Google Scholar] [CrossRef]
  24. Kulecka, M.; Fraczek, B.; Balabas, A.; Czarnowski, P.; Lubecka, Z.N.; Zapala, B.; Baginska, K.; Glowienka, M.; Szot, M.; Skorko, M.; Kluska, A.; Piatkowska, M.; Mikula, M.; Ostrowski, J. Characteristics of the gut microbiome in esports players compared with those in physical education students and professional athletes. Frontiers in Nutrition 2023, 16, 1–16. [Google Scholar] [CrossRef]
  25. Ribeiro, F.; Teixeira, R.; Poínhos. Dietary Habits and Gaming Behaviors of Portuguese and Brazilian Esports Players. Nutrients. 2023, 15, 1–20. [Google Scholar] [CrossRef]
  26. Fairbairn, P.; Dyall, S.C.; Tsofliou, F. The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis. British Journal of Nutrition 2022, 129, (428–441. [Google Scholar] [CrossRef] [PubMed]
  27. Arslan, S.; Atan, R.M.; Sahin, N.; Ergul, Y. Evaluation of night eating syndrome and food addiction in esports players. European Journal of Nutrition 2024, 63, 1–10. [Google Scholar] [CrossRef] [PubMed]
  28. Malik, M.; Tlustos, P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients 2022, 14, 1–28. [Google Scholar] [CrossRef] [PubMed]
  29. Emerson, K.; Ojalvo, S.P.; Greenberg, D. Effects of a Bonded Arginine Silicate Inositol combination (nooLVL ®) on Cognitive function in esports Gamers. The FASEB Journal 2022, 13(S1), R1939. [Google Scholar] [CrossRef]
  30. Ribeiro, F.; Poínhos, R. Nootropic supplements for esports. International Journal for Vitamin and Nutrition Research 2023, 94(3-4), 275–295. [Google Scholar] [CrossRef]
  31. Sowinski, R.; Gonzalez, D.; Xing, D.; Yoo, C.; Jenkins, V.; Nottingham, K.; Dickerson, B.; Humphries, M.; Leonard, M.; Ko, J.; Faries, M.; Kephart, W.; Rasmussen, J.C.; Kreider, B.R. Effects of Inositol-Enhanced Bonded Arginine Silicate Ingestion on Cognitive and Executive Function in Gamers. Nutrients 2021, 13, 1–14. [Google Scholar] [CrossRef]
  32. Tartar, L.J.; Kalman, D.; Hewlings, S. A Prospective Study Evaluating the Effects of a Nutritional Supplement Intervention on Cognition, Mood States, and Mental Performance in Video Gamers. Nutrients 2019, 11, 1–14. [Google Scholar] [CrossRef]
  33. Rogers, E.J.; Trotter, M.G.; Johnson, D.; Desbrow, B.; King, N. Caffeine improves the shooting performance and reaction time of first-person shooter esports players: a dose-response study. Frontiers in Sports and Active Living 2024, 10, 1–12. [Google Scholar] [CrossRef]
  34. Wu, S.H.; Chen, Y.C.; Chen, C.H.; Liu, H.S.; Liu, Z.X.; Chiu, C.H. Caffeine supplementation improves the cognitive abilities and shooting performance of elite e-sports players: a crossover trial. Scientific Reports 2024, 24, 1–7. [Google Scholar] [CrossRef]
  35. Wax, B.; Kerksick, C.M.; Jagim, A.R.; Mayo, J.J.; Lyons, B.C.; Kreider, R.B. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients 2021, 13, 1–42. [Google Scholar] [CrossRef]
  36. Nejad, A.G.; Matusch, A.; Kleedörfer, S.; Patel, H.J.; Drzezga, A.; Elmenhorst, D.; Binkofski, F.; Bauer, A. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Scientific Reports 2024, 14, 1–15. [Google Scholar] [CrossRef]
  37. Anjelic, B.; Todorovic, N.; Vranes, M.; Ostojic, S.M. Creatine-Guanidinoacetic Acid Supplementation Improves Esports Performance in Young Men. Current Nutrition & Food Science 2025, 22, 1075–1080. [Google Scholar] [CrossRef]
  38. Jeyakodi, S.; Krishnakumar, A.; Dalal, M.; Shetty, B.S. Assessment of Efficacy and Safety of Mangifera indica Extract (Stadice®) for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Study. Cureus 2024, 16, 1–13. [Google Scholar] [CrossRef] [PubMed]
  39. Stringham, J.; Hammond, B.R. Dietary lutein and zeaxanthin: possible effects on visual function. Nutrition Reviews 2005, 63, 59–64. [Google Scholar] [CrossRef] [PubMed]
  40. Thompson, C.; Wylie, L.; Fulford, J.; Kelly, J.; Black, M.; McDonagh, S.T.J.; Jeukendrup, A.E.; Vanhatalo, A.; Jones, A.M. Dietary nitrate improves cognitive function during prolonged exercise. European Journal of Applied Physiology 2015, 115(9), 1825–1834. [Google Scholar] [CrossRef]
  41. Wightman, E. L.; Ramsay, C.F.H.; Thompson, K.G.; Blackwell, J.R.; Winyard, P.G.; Forster, J.; Jones, A.M.; Kennedy, O.D. Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Physiology & Behavior 2015, 149, 149–158. [Google Scholar] [CrossRef]
  42. Lamport, D.J.; Williams, C.M. Polyphenols and Cognition In Humans: An Overview of Current Evidence from Recent Systematic Reviews and Meta-Analyses. Brain Plasticity 2021, 6, 139–153. [Google Scholar] [CrossRef]
  43. Socci, V.; Tempesta, D.; Desideri, G.; De Gennaro, L.; Ferrara, M. Enhancing human cognition with cocoa flavonoids. Frontiers in Nutrition 2017, 4(1), 1–7. [Google Scholar] [CrossRef]
  44. Spencer, S.J.; Korosi, A.; Laye, S.; Shukitt-Hale, B.; Barrientos, R.M. Food for thought: how nutrition impacts cognition and emotion. NPJ Science of Food. 2017, 1, 1–8. [Google Scholar] [CrossRef]
  45. Gómez-Pinilla, F. Brain foods: the effects of nutrients on brain function. Nature Reviews Neuroscience 2008, 9, 568–578. [Google Scholar] [CrossRef]
  46. Fu, J.; Tan, L.J.; Lee, J.E.; Shin, S. Association between the mediterranean diet and cognitive health among healthy adults: A systematic review and meta-analysis. Frontiers in Nutrition 2022, 9, 1–17. [Google Scholar] [CrossRef]
  47. Fekete, M.; Lehoczki, A.; Major, D.; Pongor, V.F.; Csipo, T.; Tarantini, S.; Csizmadia, Z.; Varga, J.T. Exploring the Influence of Gut-Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics. Nutrients 2024, 16, 1–22. [Google Scholar] [CrossRef]
  48. Banyai, F.; Griffiths, M.D.; Kiraly, O.; Demetrovics, Z. The Psychology of Esports: A Systematic Literature Review. Journal of Gambling Studies 2019, 35, 351–365. [Google Scholar] [CrossRef]
  49. Bediou, B.; Adams, D. M.; Mayer, R. E.; Tipton, E.; Green, C. S.; Bavelier, D. Meta-analysis of action video game impact on perceptual, attentional, and cognitive skills. Psychological Bulletin. 2018, 144, 77–110. [Google Scholar] [CrossRef]
  50. Puce, L.; Ceylan, H.I.; Trompetto, C.; Cotellessa, F.; Schenone, C.; Marinelli, L.; Zmijewski, P.; Bragazzi, N.L.; Mori, L. Optimizing athletic performance through advanced nutrition strategies: can AI and digital platforms have a role in ultraendurance sports? Biology of Sport. 2024, 41, 305–313. [Google Scholar] [CrossRef]
  51. Solomon, T.P.; Laye, M.J. The sports nutrition knowledge of large language model (LLM) artificial intelligence (AI) chatbots: An assessment of accuracy, completeness, clarity, quality of evidence, and test-retest reliability. PLoS One 2025, 20, 1–28. [Google Scholar] [CrossRef]
  52. Rana, I.; Parsai, A. Doping in eSports: need for a techno legal synchrony. The International Sports Law Journal. 2023, 23, 214–224. [Google Scholar] [CrossRef]
Table 1. Summary of Empirical Studies Included in the Narrative Review.
Table 1. Summary of Empirical Studies Included in the Narrative Review.
Author . Country Study Design Population (N) Key Outcome Main Findings
Goulart et al., 2023 USA Cross-sectional 119 esports athletes Dietary intake & cognition Higher intake of PUFA, selenium, zinc, B-vitamins, and vegetables was associated with better cognitive performance; poor sleep negatively associated with performance
Ribeiro et al., 2023 Portugal Cross-sectional 579 esports players Dietary patterns & gaming behavior Low adherence to Mediterranean diet; high fast-food and soft drink consumption; 32% reported supplement use
Szot et al., 2023 Poland Cohort 233 male esports athletes Dietary patterns Predominantly Western-type dietary patterns; low intake of brain-supportive foods
Soffner et al., 2023 Germany Cross-sectional 817 gamers (including 210 esports athletes) Diet & lifestyle behaviors High sedentary time; frequent energy drink intake; suboptimal fruit and fish consumption; ~25% reported low mental wellbeing
Arslan et al., 2023 Turkey Cross-sectional 248 esports players Eating behaviors & sleep Frequent meal skipping and night eating associated with longer gaming duration and poorer sleep
Kulecka et al., 2023 Poland Cross-sectional 109 esports players Diet & gut microbiome Lower energy and protein intake; reduced microbial diversity and SCFA levels compared with traditional athletes
Tartar et al., 2019 USA Randomized, double-blind, placebo-controlled trial 60 gamers Arginine (1500 mg) + Inositol (100 mg) Improved executive function and mood; no significant improvement in in-game performance compared with placebo
Sowinski et al., 2021 USA Randomized, double-blind, crossover trial 26 esports athletes Arginine (1500 mg) + Inositol (100 mg) Improved inhibitory control and working memory; no major adverse effects reported
Rogers et al., 2024 Australia Randomized, single-blind, crossover trial 24 FPS players Caffeine (1 mg/kg & 3 mg/kg) Improved reaction time, aiming performance, vigilance, and alertness; reduced perceived fatigue
Wu et al., 2024 Taiwan Randomized, single-blind, crossover trial 9 male esports athletes Caffeine (3 mg/kg) Improved reaction time, shooting accuracy, kill ratio, and visual search performance
Jeyakodi et al., 2024 India Randomized, single-blind, crossover trial 60 male gamers Mangifera indica extract (300 mg daily, 7 days) Improved processing speed, attention, and verbal learning; no significant between-group cortisol differences
Trotter et al., 2020 Australia & Sweden Cross-sectional survey 1,772 gamers General health, BMI & physical activity Higher in-game rank associated with greater gaming frequency and lower BMI; limited associations with perceived health, smoking, or alcohol use
Nicholson et al., 2024 Australia Experimental laboratory study 13 elite male esports athletes Physiological response to gameplay Competitive gameplay increased heart rate, energy expenditure, and oxygen consumption compared with rest; no major HRV changes
Lachowicz et al., 2024 Poland Experimental intervention study 52 amateur gamers Visuomotor coordination & reaction VR training improved visuomotor coordination and accuracy; some effects maintained at follow-up
Pereira et al., 2021 Portugal Cross-sectional study (SEM analysis) 292 esports football players Mental distress & coping strategies 25% reported depressive symptoms; 50% sleep disturbances; dysfunctional coping associated with anxiety, alcohol use, and poor dietary habits
Lam et al., 2022 China Cross-sectional study 50 elite male esports athletes Musculoskeletal pain & fatigue High prevalence of neck pain, eye strain, headaches, and fatigue; most symptoms were mild
Diviani et al., 2025 International (92 countries) Cross-sectional survey 488 gamers/esports participants Hearing behaviors & risk awareness High exposure to loud audio levels; frequent tinnitus and ear pressure; limited protective behaviors despite high awareness
Table 1 summarizes the primary empirical studies included in this narrative review, outlining study design, population characteristics, key outcomes, and principal findings.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Prerpints.org logo

Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.

Subscribe

Disclaimer

Terms of Use

Privacy Policy

Privacy Settings

© 2026 MDPI (Basel, Switzerland) unless otherwise stated