Submitted:
23 February 2026
Posted:
25 February 2026
You are already at the latest version
Abstract
Keywords:
1. Introduction
2. Review Design and Literature Search Strategy
3. Psychophysical Health and Lifestyle Behaviors
4. Nutrition and Cognitive and Physiological Function
4.1. Macronutrients and Micronutrients
4.2. Dietary Patterns
4.3. Mental Health and Nutrition
4.4. Dietary Supplements
4.5. Caffeine
4.6. Amino Acids
4.7. Creatine
4.7. Herbs and Plant-Derived Bioactives
| Supplement | Proposed Mechanism | Primary Effect (s) | Level of Evidence | Key Considerations |
| Caffeine | Adenosine receptor antagonism; Increase CNS arousal | Improved reaction time, sustained attention, vigilance, aiming accuracy [31,33,34] | High | Anxiety, sleep disruption, dose timing; critical requires individualized dosing. |
| Arginine | Nitric oxide pathway; possible neurovascular effects | Improved accuracy, reduced impulsivity [29,30,31,32] | Moderate | Small samples; short duration |
| Inositol | Modulation of neurotransmitter signaling | Improved attentional control [29,30,31,32] | Moderate | Limited replication |
| Creatine Monohydrate | Enhanced cerebral ATP resynthesis; energy buffering | Improved processing speed and executive function [35,36,37] | Emerging | Dose-response unclear; larger RCTs needed |
| Mangifera indica extract | Polyphenol activity; anti-fatigue mechanisms | Improved working memory, reduced mental fatigue [38] | Emerging | Product standardization variability and potential contamination risks |
| Lutein | Neuroprotective carotenoid; visual processing support | Improved visual processing speed and contrast sensitivity [39] | Emerging | Long-term intake required; specifically relevant for eye health |
| Beetroot-derived nitrates | Increase cerebral blood flow; endothelial function | Potential support for sustained attention, cerebral blood flow, oxygen efficiency [40,41] | Low/Extrapolated | Mechanism plausible; limited esports trials |
| Polyphenol-rich compounds (coca, berries) | Antioxidant; improved cerebral perfusion | Short-term improvements in attention and executive function [42,43] | Low/Preliminary | Variability in dosing and bioactive content |
5. Discussion
6. Conclusion
7. Limitations and Future Research Directions
8. Key Takeaways for Practitioners
- Prioritize nutritional foundations before supplementation.
- Use supplementation as a targeted, individualized tool.
- Protect sleep as a non-negotiable performance resource.
- Integrate structured physical conditioning and ergonomics into daily routines.
- Address stress management and coping skills explicitly.
- Adopt a holistic, player-centered support model.
- Recognize that performance gains do not always come from more gameplay.
- Embrace personalization as a core principle.
Author Contributions
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflict of Interest
References
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| Author . | Country | Study Design | Population (N) | Key Outcome | Main Findings |
| Goulart et al., 2023 | USA | Cross-sectional | 119 esports athletes | Dietary intake & cognition | Higher intake of PUFA, selenium, zinc, B-vitamins, and vegetables was associated with better cognitive performance; poor sleep negatively associated with performance |
| Ribeiro et al., 2023 | Portugal | Cross-sectional | 579 esports players | Dietary patterns & gaming behavior | Low adherence to Mediterranean diet; high fast-food and soft drink consumption; 32% reported supplement use |
| Szot et al., 2023 | Poland | Cohort | 233 male esports athletes | Dietary patterns | Predominantly Western-type dietary patterns; low intake of brain-supportive foods |
| Soffner et al., 2023 | Germany | Cross-sectional | 817 gamers (including 210 esports athletes) | Diet & lifestyle behaviors | High sedentary time; frequent energy drink intake; suboptimal fruit and fish consumption; ~25% reported low mental wellbeing |
| Arslan et al., 2023 | Turkey | Cross-sectional | 248 esports players | Eating behaviors & sleep | Frequent meal skipping and night eating associated with longer gaming duration and poorer sleep |
| Kulecka et al., 2023 | Poland | Cross-sectional | 109 esports players | Diet & gut microbiome | Lower energy and protein intake; reduced microbial diversity and SCFA levels compared with traditional athletes |
| Tartar et al., 2019 | USA | Randomized, double-blind, placebo-controlled trial | 60 gamers | Arginine (1500 mg) + Inositol (100 mg) | Improved executive function and mood; no significant improvement in in-game performance compared with placebo |
| Sowinski et al., 2021 | USA | Randomized, double-blind, crossover trial | 26 esports athletes | Arginine (1500 mg) + Inositol (100 mg) | Improved inhibitory control and working memory; no major adverse effects reported |
| Rogers et al., 2024 | Australia | Randomized, single-blind, crossover trial | 24 FPS players | Caffeine (1 mg/kg & 3 mg/kg) | Improved reaction time, aiming performance, vigilance, and alertness; reduced perceived fatigue |
| Wu et al., 2024 | Taiwan | Randomized, single-blind, crossover trial | 9 male esports athletes | Caffeine (3 mg/kg) | Improved reaction time, shooting accuracy, kill ratio, and visual search performance |
| Jeyakodi et al., 2024 | India | Randomized, single-blind, crossover trial | 60 male gamers | Mangifera indica extract (300 mg daily, 7 days) | Improved processing speed, attention, and verbal learning; no significant between-group cortisol differences |
| Trotter et al., 2020 | Australia & Sweden | Cross-sectional survey | 1,772 gamers | General health, BMI & physical activity | Higher in-game rank associated with greater gaming frequency and lower BMI; limited associations with perceived health, smoking, or alcohol use |
| Nicholson et al., 2024 | Australia | Experimental laboratory study | 13 elite male esports athletes | Physiological response to gameplay | Competitive gameplay increased heart rate, energy expenditure, and oxygen consumption compared with rest; no major HRV changes |
| Lachowicz et al., 2024 | Poland | Experimental intervention study | 52 amateur gamers | Visuomotor coordination & reaction | VR training improved visuomotor coordination and accuracy; some effects maintained at follow-up |
| Pereira et al., 2021 | Portugal | Cross-sectional study (SEM analysis) | 292 esports football players | Mental distress & coping strategies | 25% reported depressive symptoms; 50% sleep disturbances; dysfunctional coping associated with anxiety, alcohol use, and poor dietary habits |
| Lam et al., 2022 | China | Cross-sectional study | 50 elite male esports athletes | Musculoskeletal pain & fatigue | High prevalence of neck pain, eye strain, headaches, and fatigue; most symptoms were mild |
| Diviani et al., 2025 | International (92 countries) | Cross-sectional survey | 488 gamers/esports participants | Hearing behaviors & risk awareness | High exposure to loud audio levels; frequent tinnitus and ear pressure; limited protective behaviors despite high awareness |
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