A Novel Skin Glow Complex Attenuates UV-Induced Damage and Melanogenesis in Human Skin Models

Melanogenesis is a highly complex process regulated by multiple signaling pathways that control melanin synthesis in melanocytes and its subsequent transfer to keratinocytes. This process is further influenced by an intricate network of interactions among various skin cell populations, including inflammatory cells, which release paracrine factors in response to internal and external stimuli, such as UV radiation. The aim of this study was to evaluate effectiveness a new cosmetic formulation Skin Glow Complex designed for the topical treatment of skin dyschromia. We investigated the potential benefits of the for-mulation in two major resident skin cell types, keratinocytes and fibroblasts subjected to UV irradiation. Additionally, its effects were tested in 3D human melanocyte spheroid model, that better mimics the skin's environment. Treatment with the new formulation prevented UV-induced reactive oxygen species (ROS) formation in keratinocytes. In dermal fibroblasts, the formulation decreased the expression of matrix metalloproteinases while simultaneously promoting cell proliferation and collagen synthesis. Finally, results obtained from the melanocyte spheroid model confirmed the formulation’s ability to reduce melanin production, reinforcing its potential use in the treatment of skin dyschromia. Overall, these findings indicate that the new product represents a promising natural option to support skin repair and counteract aging and UV-induced damage.