Submitted:
13 July 2025
Posted:
14 July 2025
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Abstract
Keywords:
Introduction
Materials and Methods
Results
Discussion
Conclusions
Author Contributions
Acknowledgements
Conflicts of interest
References
- Mistiaen, P.; Heede, K.V.D. Nutrition Support Teams: A Systematic Review. J. Parenter. Enter. Nutr. 2020, 44, 1004–1020. [Google Scholar] [CrossRef] [PubMed]
- Cederholm, T.; Jensen, G.L.; Correia, M.I.T.D.; Gonzalez, M.C.; Fukushima, R.; Higashiguchi, T.; Baptista, G.; Barazzoni, R.; Blaauw, R.; Coats, A.J.; et al. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. Clin Nutr. 2019, 38, 1–9. [Google Scholar] [CrossRef] [PubMed]
- Kagansky, N.; Berner, Y.; Koren-Morag, N.; Perelman, L.; Knobler, H.; Levy, S. Poor nutritional habits are predictors of poor outcome in very old hospitalized patients. Am. J. Clin. Nutr. 2005, 82, 784–791. [Google Scholar] [CrossRef] [PubMed]
- Kondrup, J.; Rasmussen, H.H.; Hamberg, O.; Stanga, Z.; Ad Hoc ESPEN Working Group. Nutritional risk screening [NRS 2002]: a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003, 22, 321–36. [Google Scholar] [CrossRef] [PubMed]
- de Mendonça Soares, B.L.; Pessoa de Araújo Burgos, M.G. Nutritional risk among surgery patients and associations with hospital stay and postoperative complications. Nutr Hosp. 2014, 30, 636–642. [Google Scholar] [CrossRef] [PubMed]
- Zhang, L.; Wang, S.; Gao, X.; Gao, T.; Huang, L.; Lian, B.; Gu, Y.; Chen, J.; Guo, D.; Jia, Z.; et al. Poor Pre-operative Nutritional Status Is a Risk Factor of Post-operative Infections in Patients With Gastrointestinal Cancer—A Multicenter Prospective Cohort Study. Front. Nutr. 2022, 9, 850063. [Google Scholar] [CrossRef] [PubMed]
- Shi, H.; Wang, X.; Kang, W.; Liu, Z.; Tang, Y.; Zhu, C.; Kerr, K.W.; Sulo, S.; Zhu, Q.; Tang, Z.; et al. Malnourished, gastrointestinal cancer patients undergoing surgery: burden of nutritional risk, use of oral nutritional supplements, and impact on health outcomes. Asia Pac J Clin Nutr. 2025, 34, 325–331. [Google Scholar] [CrossRef] [PubMed]
- Aro, R.; Ohtonen, P.; Rautio, T.; Saarnio, J.; Mäkäräinen, E.; Häivälä, R.; Mäkinen, M.J.; Tuomisto, A.; Schwab, U.; Meriläinen, S. Perioperative oral nutritional support for patients diagnosed with primary colon adenocarcinoma undergoing radical surgical procedures -Peri-Nutri Trial: study protocol for a randomized controlled trial. BMC Nutr. 2022, 8, 1–11. [Google Scholar] [CrossRef] [PubMed]
- Inoue, T.; Misu, S.; Tanaka, T.; Kakehi, T.; Ono, R. Acute phase nutritional screening tool associated with functional outcomes of hip fracture patients: A longitudinal study to compare MNA-SF, MUST, NRS-2002 and GNRI. Clin. Nutr. 2019, 38, 220–226. [Google Scholar] [CrossRef] [PubMed]
- Browne, R.M. The odontogenic keratocyst. Histological features and their correlation with clinical behaviour. Br. Dent. J. 1971, 131, 249–259. [Google Scholar] [CrossRef] [PubMed]
- Matsuki, Y.; Ichihara, H.; Toida, M.; Fujitsuka, H.; Suwa, T.; Tatematsu, N. Odontogenic keratocysts. Clinical and pathological studies of 29 cases. Jpn. J. Oral Maxillofac. Surg. 2000, 46, 232–234. [Google Scholar] [CrossRef]
- Iseki, T.; Hayashi, T.; Tsuji, K.; Matsushita, Y.; Iwai, R.; Kuroda, T.; Yamada, K.; Matsumoto, K.; Yoshida, H.; Wato, M.; Tanaka, A.; Morita, S. Clinical analysis of keratocystic odontogenic tumors treated at Osaka Dental University. J Osaka Dent Univ. 2017, 51, 17–22. [Google Scholar]
- Maeda, K.; Ishida, Y.; Nonogaki, T.; Mori, N. Reference body mass index values and the prevalence of malnutrition according to the Global Leadership Initiative on Malnutrition criteria. Clin. Nutr. 2020, 39, 180–184. [Google Scholar] [CrossRef] [PubMed]
- Schuetz, P.; Fehr, R.; Baechli, V.; Geiser, M.; Deiss, M.; Gomes, F.; Kutz, A.; Tribolet, P.; Bregenzer, T.; Braun, N.; et al. Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial. Lancet 2019, 393, 2312–2321. [Google Scholar] [CrossRef] [PubMed]
- Shigeishi, H.; Ohta, K.; Takechi, M. Risk factors for postoperative complications following oral surgery. J. Appl. Oral Sci. 2015, 23, 419–423. [Google Scholar] [CrossRef] [PubMed]
- White, J.V.; Guenter, P.; Jensen, G.; Malone, A.; Schofield, M. Consensus statement: Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition: Characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). JPEN J. Parenter. Enter. Nutr. 2012, 36, 275–283. [Google Scholar] [CrossRef] [PubMed]
- Taylor, B.E.; McClave, S.A.; Martindale, R.G.; Warren, M.M.; Johnson, D.R.; Braunschweig, C.; McCarthy, M.S.; Davanos, E.; Rice, T.W.; Cresci, G.A.; et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient. Crit. Care Med. 2016, 44, 390–438. [Google Scholar] [CrossRef] [PubMed]
- Evans, D.C.; Corkins, M.R.; Malone, A.; Miller, S.; Mogensen, K.M.; Guenter, P.; Jensen, G.L.; the ASPEN Malnutrition Committee. The Use of Visceral Proteins as Nutrition Markers: An ASPEN Position Paper. Nutr. Clin. Practice 2021, 36, 22–28. [Google Scholar] [CrossRef] [PubMed]



| Total [n=548] | Men [n=224] | Women [n=324] | P | ||
|---|---|---|---|---|---|
| Age [years-old] | 35.1±17.0 | 36.3±17.2 | 34.4±16.8 | 0.200 | |
| Height [cm] | 162.8±10.7 | 169.5±10.8 | 158.3±7.8 | <0.001 | |
| Weight [kg] | 59.9±14.4 | 68.1±14.9 | 54.2±10.9 | <0.001 | |
| Body Mass Index [BMI] | 22.4±4.2 | 23.6±4.4 | 21.6±3.8 | <0.001 | |
| Length of Hospital Stay [days] | 6.2±4.8 | 5.6±4.0 | 6.5±5.3 | 0.026 | |
| Purpose of Hospitalization | Jaw Deformity, n[%] | 157 [28.6] | 48 [21.4] | 109 [33.6] | 0.002 |
| Jaw Deformity [Plate Removal], n[%] | 80 [14.6] | 23 [10.3] | 57 [17.6] | 0.019 | |
| Tooth Extraction, n[%] | 118 [21.5] | 47 [21.0] | 71 [21.9] | 0.833 | |
| Cystic Lesion, n[%] | 115 [21.0] | 71 [31.7] | 44 [13.6] | <0.001 | |
| Inflammatory Disease, n[%] | 22 [4.0] | 8 [3.6] | 14 [4.3] | 0.826 | |
| Mucosal Disease, n[%] | 8 [1.5] | 5 [2.2] | 3 [0.9] | 0.282 | |
| Malignant Tumor, n[%] | 9 [1.6] | 5 [2.2] | 4 [1.2] | 0.497 | |
| Benign Tumor, n[%] | 21 [3.8] | 10 [4.5] | 11 [3.4] | 0.652 | |
| Others [e.g., trauma, foreign body, etc.], n[%] | 18 [3.3] | 7 [3.1] | 11 [3.4] | 1.000 | |
| NRS-2002 Score ≥ 3, n[%] | 9 [1.6] | 2 [0.9] | 7 [2.2] | 0.321 | |
| Case | NRS-2002 Score | Diagnosis | Height [cm] |
Weight [kg] |
BMI | Length of Hospital Stay [days] | Malnutrition According to GLIM Criteria | Treatment Details |
|---|---|---|---|---|---|---|---|---|
| 73M | 3 | Persistent oral bleeding after scaling | 171.8 | 50.8 | 17.2 | 7 | Applicable | The diet was gradually modified to easier-to-swallow consistencies according to the patient's condition. To ensure adequate nutritional intake, oral nutritional supplements [ONS] were added to each meal. |
| 83F | 3 | Cellulitis at left mandible | 144.5 | 46 | 22.0 | 4 | Not Applicable | The patient was admitted on an emergency basis due to inflammation. With improvement in symptoms through treatment, the patient was able to consume over 50% of a soft diet consisting of porridge and finely chopped foods at discharge. |
| 37F | 3 | Fibrous dysplasia of right mandible | 165 | 60 | 22.0 | 15 | Not Applicable | To stimulate appetite, seaweed paste was added to the staple food. Additionally, one Calorie Mate jelly [200 kcal] was provided with breakfast. |
| 59F | 3 | Cellulitis at oral floor | 149.5 | 49.8 | 22.3 | 7 | Not Applicable | Due to inflammation, emergency admission was required. Oral intake remained poor; thus, one serving of a concentrated ONS [200 kcal] was added to each meal of porridge and finely minced foods. As intake did not improve, the meal texture was further softened to rice gruel and a mousse-type side dish, with Calorie Mate jelly [200 kcal] added to each meal. With a decline in inflammatory markers, food intake improved, accompanied by weight gain. |
| 85F | 3 | Osteomyelitis of mandible | 155 | 30.7 | 12.8 | 25 | Applicable | Anti-inflammatory treatment was initiated. ONS [200 kcal] was added to each meal of porridge and chopped foods. The patient's oral intake was favorable, with a 2.6 kg weight gain compared to admission. |
| 83F | 3 | Cellulitis at oral floor | 148 | 40.9 | 18.7 | 5 | Applicable | The patient was admitted emergently due to inflammation and was able to consume 80–100% of a regular diet. |
| 74M | 4 | Sinusitis at left side | 160 | 48.8 | 19.1 | 3 | Not Applicable | The patient had diabetes and was treated with insulin. A diabetic diet of 1,400 kcal was fully consumed, and blood glucose levels remained stable throughout hospitalization. |
| 91F | 4 | Medication-Related Osteonecrosis of the Jaw [MRONJ] | 143 | 44.8 | 21.9 | 63 | Not Applicable | During a prolonged hospitalization of approximately two months, serum total protein levels declined postoperatively. However, one ONS was added to each meal, and oral intake was maintained. Meal texture was gradually upgraded based on the patient's condition. At discharge, the patient was able to consume soft rice and soft vegetables, with body weight maintained. |
| 75F | 4 | Osteomyelitis of mandible | 152 | 42.5 | 18.4 | 10 | Applicable | Due to hyponatremia, pickled plum paste was added to each meal. After surgery, the patient transitioned from enteral nutrition to oral intake, which was well tolerated. Serum sodium levels gradually improved. |
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