Version 1
: Received: 27 May 2024 / Approved: 27 May 2024 / Online: 27 May 2024 (15:48:26 CEST)
How to cite:
De los Santos-Jiménez, J.; Campos-Sandoval, J. A.; Alonso, F. J.; Márquez, J.; Matés, J. M. GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells. Preprints2024, 2024051789. https://doi.org/10.20944/preprints202405.1789.v1
De los Santos-Jiménez, J.; Campos-Sandoval, J. A.; Alonso, F. J.; Márquez, J.; Matés, J. M. GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells. Preprints 2024, 2024051789. https://doi.org/10.20944/preprints202405.1789.v1
De los Santos-Jiménez, J.; Campos-Sandoval, J. A.; Alonso, F. J.; Márquez, J.; Matés, J. M. GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells. Preprints2024, 2024051789. https://doi.org/10.20944/preprints202405.1789.v1
APA Style
De los Santos-Jiménez, J., Campos-Sandoval, J. A., Alonso, F. J., Márquez, J., & Matés, J. M. (2024). GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells. Preprints. https://doi.org/10.20944/preprints202405.1789.v1
Chicago/Turabian Style
De los Santos-Jiménez, J., Javier Márquez and José M Matés. 2024 "GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells" Preprints. https://doi.org/10.20944/preprints202405.1789.v1
Abstract
A pathway frequently altered in cancer is glutaminolysis where glutaminase (GA) catalyses the main step: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named GLS and GLS2, which differ considerably in their expression patterns and can even perform opposing roles in cancer. GLS correlates with tumor growth and proliferation, while GLS2 may function as a context-dependent tumor suppressor. However, both isoenzymes have been described as essential molecules handling oxidant stress because of their involvement in glutathione production. We have reviewed the literature to highlight the critical roles of GLS and GLS2 to restrain ROS and regulate both cellular signaling and metabolic stress due to their function as indirect antioxidant enzymes and also by modulating both reductive carboxylation and ferroptosis. Blocking GA activity appears to be a potential strategy to dual activate ferroptosis and inhibit cancer cell growth in a ROS-mediated mechanism.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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