Version 1
: Received: 23 May 2024 / Approved: 24 May 2024 / Online: 24 May 2024 (11:54:56 CEST)
How to cite:
Uddin, M. S.; Khand, S.; Dong, C. Effect of Crosslinking Agents on Chitosan Hydrogel Carrier for Drug Loading and Releasing for Targeted Drug Delivery. Preprints2024, 2024051644. https://doi.org/10.20944/preprints202405.1644.v1
Uddin, M. S.; Khand, S.; Dong, C. Effect of Crosslinking Agents on Chitosan Hydrogel Carrier for Drug Loading and Releasing for Targeted Drug Delivery. Preprints 2024, 2024051644. https://doi.org/10.20944/preprints202405.1644.v1
Uddin, M. S.; Khand, S.; Dong, C. Effect of Crosslinking Agents on Chitosan Hydrogel Carrier for Drug Loading and Releasing for Targeted Drug Delivery. Preprints2024, 2024051644. https://doi.org/10.20944/preprints202405.1644.v1
APA Style
Uddin, M. S., Khand, S., & Dong, C. (2024). Effect of Crosslinking Agents on Chitosan Hydrogel Carrier for Drug Loading and Releasing for Targeted Drug Delivery. Preprints. https://doi.org/10.20944/preprints202405.1644.v1
Chicago/Turabian Style
Uddin, M. S., Suyash Khand and Chao Dong. 2024 "Effect of Crosslinking Agents on Chitosan Hydrogel Carrier for Drug Loading and Releasing for Targeted Drug Delivery" Preprints. https://doi.org/10.20944/preprints202405.1644.v1
Abstract
Numerous study reports on chitosan hydrogels in different forms such as films, porous structures, nanoparticles, and microspheres for biomedical applications, however, this study concentrates on their modifications with different crosslinking agents and observing their effects on drug loading and releasing capacities. Linear chitosan along with crosslinked by two major cross-linkers, i.e., genipin and disulfide have been used to formulate three different hydrogel systems. The cross-linking process is heavily impacted by the temperature and the pH conditions. Three different drugs, i.e., thymoquinone, gefitinib, and erlotinib are loaded in phosphate buffer solutions and infused with three different hydrogel systems, thus, a total of nine combinations are studied and analyzed for drug loading and releasing capabilities with Ultraviolet–visible (UV-Vis) spectroscopy. This study finds thymoquinone shows the lowest loading efficacy compared to two other drugs in all three systems. Gefitinib shows stable loading and releasing regardless of crosslinking systems and genipin crosslinked system shows stable loading and releasing with all three drug molecules. These experimental results agree well with the findings of our previously published results conducted with molecular dynamics simulations.
Keywords
Targeted drug delivery; Chitosan; hydrogel; crosslinking agent; Cancer
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
