Version 1
: Received: 24 May 2024 / Approved: 24 May 2024 / Online: 24 May 2024 (14:10:32 CEST)
How to cite:
Khalfallah, H. B.; Jelassi, M.; Rissaoui, H.; Barchouchi, M.; Baraille, C.; Gardes, J.; Demongeot, J. Information Gradient among Nucleotide Sequences of Essential RNAs in an Evolutionary Perspective. Preprints2024, 2024051634. https://doi.org/10.20944/preprints202405.1634.v1
Khalfallah, H. B.; Jelassi, M.; Rissaoui, H.; Barchouchi, M.; Baraille, C.; Gardes, J.; Demongeot, J. Information Gradient among Nucleotide Sequences of Essential RNAs in an Evolutionary Perspective. Preprints 2024, 2024051634. https://doi.org/10.20944/preprints202405.1634.v1
Khalfallah, H. B.; Jelassi, M.; Rissaoui, H.; Barchouchi, M.; Baraille, C.; Gardes, J.; Demongeot, J. Information Gradient among Nucleotide Sequences of Essential RNAs in an Evolutionary Perspective. Preprints2024, 2024051634. https://doi.org/10.20944/preprints202405.1634.v1
APA Style
Khalfallah, H. B., Jelassi, M., Rissaoui, H., Barchouchi, M., Baraille, C., Gardes, J., & Demongeot, J. (2024). Information Gradient among Nucleotide Sequences of Essential RNAs in an Evolutionary Perspective. Preprints. https://doi.org/10.20944/preprints202405.1634.v1
Chicago/Turabian Style
Khalfallah, H. B., Joël Gardes and Jacques Demongeot. 2024 "Information Gradient among Nucleotide Sequences of Essential RNAs in an Evolutionary Perspective" Preprints. https://doi.org/10.20944/preprints202405.1634.v1
Abstract
We hypothesize that the first ancestral "ante-cell" molecular structures, i.e., first RNAs and peptides which gradually transformed into real cells once the Earth had cooled sufficiently for organic molecules to appear there, have leaved traces in RNAs and genes of present cells. We propose a circular RNA which could have been one of these ancestral structures whose vestigial pentameric subsequences would mark the evolution from this key moment when the ante-cells have begun to join the living organisms. In particular, we propose that in present RNAs (ribosomal or messenger) playing an important role in the metabolism of current cells, we look for traces of the proposed primitive structure in the form of pentamers (or longer fragments) belonging to their nucleotide sequence. The result obtained can be summarized in the existence of a gradient of occurrence of such pentamers, with a high frequency for the most vital functions (protein synthesis, nucleic synthesis, cell respiration, etc.). This gradient is also visible between organisms, from the oldest (Archaea) to the most recent (Eukaryotes) in evolution of species.
Keywords
Origin of life; Proto-ribosome; RNA ring; Prebiotic systems; Gradient of pentamer frequency
Subject
Biology and Life Sciences, Ecology, Evolution, Behavior and Systematics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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