Version 1
: Received: 19 May 2024 / Approved: 20 May 2024 / Online: 20 May 2024 (12:56:50 CEST)
How to cite:
McLean, A. K.; Reynolds, G.; Pratt, A. G. Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases. Preprints2024, 2024051276. https://doi.org/10.20944/preprints202405.1276.v1
McLean, A. K.; Reynolds, G.; Pratt, A. G. Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases. Preprints 2024, 2024051276. https://doi.org/10.20944/preprints202405.1276.v1
McLean, A. K.; Reynolds, G.; Pratt, A. G. Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases. Preprints2024, 2024051276. https://doi.org/10.20944/preprints202405.1276.v1
APA Style
McLean, A. K., Reynolds, G., & Pratt, A. G. (2024). Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases. Preprints. https://doi.org/10.20944/preprints202405.1276.v1
Chicago/Turabian Style
McLean, A. K., Gary Reynolds and Arthur G. Pratt. 2024 "Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases" Preprints. https://doi.org/10.20944/preprints202405.1276.v1
Abstract
The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis and skin psoriasis, albeit only for subsets of individuals with each condition. This suggests intersecting "nodes" in inflammatory networks at a molecular and cellular level may drive and/or maintain IMIDs, being “shared” between traditionally distinct diagnoses without mapping neatly to a single clinical phenotype. In line with this proposition, integrative tumour tissue analyses in oncology have highlighted novel cell states acting across diverse cancers, with important implications for precision medicine. Drawing upon advances in the oncology field, this narrative review will first summarise learnings from the Human Cell Atlas in health as a platform for interrogating IMID tissues. It will then review cross-disease studies to date that inform this endeavour, before considering future directions in the field.
Keywords
immune-mediated inflammatory diseases; single-cell sequencing; multi-tissue atlas; cross-tissue atlas; human cell atlas; integrative analysis; precision medicine
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
