Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

Gabriele Zanirati; Paula Gabrielli dos Santos; Allan Marinho Alcará; Fernanda Bruzzo; Isadora Machado Ghilardi; Vinicius Wietholter; Fernando Antônio Costa Xavier; João Ismael Budelon Gonçalves; Daniel Marinowic; Ashok K Shetty; Jaderson Costa da Costa

doi:10.20944/preprints202404.1717.v1

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preprints.org > biology and life sciences > neuroscience and neurology > doi: 10.20944/preprints202404.1717.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

Gabriele Zanirati

^* ,

Paula Gabrielli dos Santos

Allan Marinho Alcará

Fernanda Bruzzo

Isadora Machado Ghilardi

Vinicius Wietholter

Fernando Antônio Costa Xavier

João Ismael Budelon Gonçalves

Daniel Marinowic

Ashok K Shetty

Jaderson Costa da Costa

Version 1 : Received: 25 April 2024 / Approved: 26 April 2024 / Online: 26 April 2024 (05:55:28 CEST)

How to cite: Zanirati, G.; dos Santos, P.G.; Alcará, A.M.; Bruzzo, F.; Ghilardi, I.M.; Wietholter, V.; Costa Xavier, F.A.; Budelon Gonçalves, J.I.; Marinowic, D.; Shetty, A.K.; da Costa, J.C. Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases. Preprints 2024, 2024041717. https://doi.org/10.20944/preprints202404.1717.v1 Zanirati, G.; dos Santos, P.G.; Alcará, A.M.; Bruzzo, F.; Ghilardi, I.M.; Wietholter, V.; Costa Xavier, F.A.; Budelon Gonçalves, J.I.; Marinowic, D.; Shetty, A.K.; da Costa, J.C. Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases. Preprints 2024, 2024041717. https://doi.org/10.20944/preprints202404.1717.v1

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MDPI and ACS Style

Zanirati, G.; dos Santos, P.G.; Alcará, A.M.; Bruzzo, F.; Ghilardi, I.M.; Wietholter, V.; Costa Xavier, F.A.; Budelon Gonçalves, J.I.; Marinowic, D.; Shetty, A.K.; da Costa, J.C. Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases. Preprints 2024, 2024041717. https://doi.org/10.20944/preprints202404.1717.v1

APA Style

Zanirati, G., dos Santos, P.G., Alcará, A.M., Bruzzo, F., Ghilardi, I.M., Wietholter, V., Costa Xavier, F.A., Budelon Gonçalves, J.I., Marinowic, D., Shetty, A.K., & da Costa, J.C. (2024). Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases. Preprints. https://doi.org/10.20944/preprints202404.1717.v1

Chicago/Turabian Style

Zanirati, G., Ashok K Shetty and Jaderson Costa da Costa. 2024 "Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases" Preprints. https://doi.org/10.20944/preprints202404.1717.v1

Abstract

It has been widely established that the characterization of extracellular vesicles (EVs), particularly small EVs (sEVs), shed by different cell types into biofluids, helps identify biomarkers and therapeutic targets in neurological and neurodegenerative diseases. Recent studies are also exploring the efficacy of mesenchymal stem cell-derived extracellular vesicles naturally enriched with therapeutic microRNAs and proteins for treating various diseases. Besides, EVs released by various neural cells play a crucial function in the modulation of signal transmission in the brain in physiological conditions. However, in pathological conditions, such EVs can facilitate the spread of pathological proteins from one brain region to the other. On the other hand, analysis of EVs in biofluids can identify sensitive biomarkers for diagnosis, prognosis, and disease progression. This review discusses the potential therapeutic use of stem cell-derived EVs in several central nervous system diseases. It lists their differences and similarities and confers various studies exploring EVs as biomarkers. Further advances in EV research in the coming years will likely lead to the routine use of EVs in therapeutic settings.

Keywords

exosomes; extracellular vesicles; diagnostic. sequencing; biomarkers

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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