Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana

How to cite: Othusitse, L.; Phinius, B.B.; Wateka, K.; Mpebe, G.; Choga, W.T.; Bhebhe, L.; Phakedi, B.; Ditshwanelo, D.; Ratsoma, T.; Baruti, K.; Jongman, M.; Lebani, K.; Moyo, S.; Anderson, M.; Gaseitsiwe, S. Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana. Preprints 2024, 2024041580. https://doi.org/10.20944/preprints202404.1580.v1 Othusitse, L.; Phinius, B.B.; Wateka, K.; Mpebe, G.; Choga, W.T.; Bhebhe, L.; Phakedi, B.; Ditshwanelo, D.; Ratsoma, T.; Baruti, K.; Jongman, M.; Lebani, K.; Moyo, S.; Anderson, M.; Gaseitsiwe, S. Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana. Preprints 2024, 2024041580. https://doi.org/10.20944/preprints202404.1580.v1

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MDPI and ACS Style

Othusitse, L.; Phinius, B.B.; Wateka, K.; Mpebe, G.; Choga, W.T.; Bhebhe, L.; Phakedi, B.; Ditshwanelo, D.; Ratsoma, T.; Baruti, K.; Jongman, M.; Lebani, K.; Moyo, S.; Anderson, M.; Gaseitsiwe, S. Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana. Preprints 2024, 2024041580. https://doi.org/10.20944/preprints202404.1580.v1

APA Style

Othusitse, L., Phinius, B.B., Wateka, K., Mpebe, G., Choga, W.T., Bhebhe, L., Phakedi, B., Ditshwanelo, D., Ratsoma, T., Baruti, K., Jongman, M., Lebani, K., Moyo, S., Anderson, M., & Gaseitsiwe, S. (2024). Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana. Preprints. https://doi.org/10.20944/preprints202404.1580.v1

Chicago/Turabian Style

Othusitse, L., Motswedi Anderson and Simani Gaseitsiwe. 2024 "Association of Hepatitis B Virus E Antigen With HBV Viral Load in Botswana" Preprints. https://doi.org/10.20944/preprints202404.1580.v1

Abstract

(1) Background: Hepatitis B virus (HBV) viral load (VL) is useful in determining treatment eligibility, however, due to high costs associated with the test, hepatitis B e antigen (HBeAg) is recommended as a proxy for HBV VL in resource-limited settings. (2) Methods: We used 299 archived plasma samples with hepatitis B surface antigen (HBsAg), HBeAg, and HBV VL (cut-off of 20,000 IU/mL and 200,000 IU/mL) results from people living with human immunodeficiency virus (PLWH). HBeAg and HBV VL results were analyzed to evaluate the use of HBeAg to determine CHB treatment eligibility and qualification of HBV prevention of mother-to-child transmission (PMTCT) prophylaxis for the first time in Botswana. (3) Results: Approximately 70.8% and 87.5% of participants with HBeAg-positive serology had HBV viral loads ≥20,000 IU/mL and 200,000 IU/mL respectively. Using logistic regression, the odds of having a qualifying HBV VL for CHB treatment and PMTCT prophylaxis were respectively 55.5 and 110.4 times higher in participants with positive HBeAg serology indicating a statistically significant association between HBeAg status and HBV VL. (4) Conclusions: HBeAg detection may not always correlate with high HBV VL, warranting further research focusing on this association, and other biomarkers that correlate better with HBV VL.

Keywords

Hepatitis B virus; HBeAg; HBV viral load; HIV; Botswana

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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